Latent infections, coronavirus disease 2019 and psychiatric disorders: The friend of my enemy.

Autor: Mofazzal Jahromi MA; Zoonoses Research Center Jahrom University of Medical Sciences Jahrom Iran.; Department of Immunology School of Medicine Jahrom University of Medical Sciences Jahrom Iran.; Department of Advanced Medical Sciences & Technologies Jahrom University of Medical Sciences Jahrom Iran., Sefidfard M; Department of Psychiatry Jahrom University of Medical Sciences Jahrom Iran.; Research Center for Noncommunicable Diseases Jahrom University of Medical Sciences Jahrom Iran., Taghipour A; Zoonoses Research Center Jahrom University of Medical Sciences Jahrom Iran.; Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran., Roustazadeh A; Department of Advanced Medical Sciences & Technologies Jahrom University of Medical Sciences Jahrom Iran.; Department of Biochemistry and Nutrition Jahrom University of Medical Sciences Jahrom Iran., Matin S; Department of Pediatrics Jahrom Iran., Mir H; Department of Advanced Medical Sciences & Technologies Jahrom University of Medical Sciences Jahrom Iran.; Department of Biochemistry and Nutrition Jahrom University of Medical Sciences Jahrom Iran., Badri M; Medical Microbiology Research Center Qazvin University of Medical Sciences Qazvin Iran., Bahrami F; Kurdistan University of Medical Sciences Kurdistan Iran., Abdoli A; Zoonoses Research Center Jahrom University of Medical Sciences Jahrom Iran.; Research Center for Noncommunicable Diseases Jahrom University of Medical Sciences Jahrom Iran.
Jazyk: angličtina
Zdroj: Clinical and translational discovery [Clin Transl Discov] 2022 Oct 13; Vol. 2 (4), pp. e141. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).
DOI: 10.1002/ctd2.141
Abstrakt: Recent reports revealed an increased rate of hospitalization and mortality of coronavirus disease 2019 (COVID-19) among patients with psychiatric disorders. On the other hand, there is a link between latent infections, including Toxoplasma gondii , herpes simplex virus type 1 (HSV-1) and cytomegalovirus (CMV) with psychiatric disorders. We individually assessed data regarding 1) the mortality rate of COVID-19 among individuals with psychiatric disorders; 2) the association of latent infections in COVID-19 patients and 3) the association between latent infections and psychiatric disorders. We developed the hypothesis that latent infection could increase the risk of severe COVID-19 among patients with psychiatric disorders. Cumulative evidence proposed that infection with toxoplasmosis, CMV and HSV-1 could increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-Co-V2) infections among patients with psychiatric disorders probably by induction of hyperinflammatory conditions. These infections are also associated with hyperinflammation and T cell exhaustion, which has also been observed in both schizophrenia and COVID-19. This hypothesis provides new insights into the role of latent infections in increasing the mortality rates of COVID-19 among individuals with psychiatric disorders. Strategies for screening, early diagnosis and treatment of these infections could be recommended for COVID-19 patients with a background of psychiatric disorders.
Competing Interests: The authors declare no conflict of interest. The paper was handled by editors and has undergone a rigorous peer‐review process. Dr. Amir Abdoli was not involved in the journal's review of/or decisions related to this manuscript.
(© 2022 The Authors. Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)
Databáze: MEDLINE
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