Normative modeling of brain morphometry in Clinical High-Risk for Psychosis.
| Autor: | Haas SS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ge R; Djavad Mowafaghian Centre for Brain Health, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada., Agartz I; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Amminger GP; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.; Orygen, Melbourne, VIC, Australia., Andreassen OA; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Bachman P; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA., Baeza I; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain., Choi S; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea., Colibazzi T; Department of Psychiatry, Columbia University, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Cropley VL; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Melbourne, VIC, Australia., de la Fuente-Sandoval C; Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico., Ebdrup BH; Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fortea A; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Fundació Clínic Recerca Biomèdica, Universitat de Barcelona, Barcelona, Spain., Fusar-Poli P; Department of Psychosis Studies, Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Glenthøj BY; Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Glenthøj LB; Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Haut KM; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA., Hayes RA; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA., Heekeren K; Department of Psychiatry and Psychotherapy, LVR-Hospital Cologne, Cologne, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland., Hooker CI; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA., Hwang WJ; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.; Catholic Kwandong University College of Medicine, Gangneung, Republic of Korea., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Kaess M; Department of Child and Adolescent Psychiatry, University of Heidelberg, Heidelberg, Germany.; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Kasai K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Institute for Diversity and Adaptation of Human Mind, The University of Tokyo, Tokyo, Japan.; The International Research Center for Neurointelligence at The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan., Katagiri N; Department of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan., Kim M; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea., Kindler J; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Koike S; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Institute for Diversity and Adaptation of Human Mind, The University of Tokyo, Tokyo, Japan., Kristensen TD; Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark., Kwon JS; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea., Lawrie SM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Lee J; Department of Psychosis, Institute of Mental Health, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Lemmers-Jansen IL; Faculty of Behavioural and Movement Sciences, Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Lin A; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Ma X; National Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China., Mathalon DH; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.; San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., McGuire P; Department of Psychiatry, University of Oxford, Oxford, UK., Michel C; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Mizrahi R; Douglas Research Center, Montreal, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Mizuno M; Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan., Møller P; Department for Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Drammen, Norway., Mora-Durán R; Emergency Department, Hospital Fray Bernardino Álvarez, Mexico City, Mexico., Nelson B; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.; Orygen, Melbourne, VIC, Australia., Nemoto T; Department of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan., Nordentoft M; Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Nordholm D; Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Omelchenko MA; Department of Youth Psychiatry, Mental Health Research Center, Moscow, Russian Federation., Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.; Florey Institute of Neuroscience and Mental Health, Center for Mental Health, Parkville, VIC, Australia., Pariente JC; Magnetic Resonance Imaging Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Raghava JM; Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.; Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, University of Copenhagen, Glostrup, Denmark., Reyes-Madrigal F; Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico., Røssberg JI; Oslo University Hospital and University of Oslo, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Rössler W; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland., Salisbury DF; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Sasabayashi D; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Schall U; Priority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre Grow Up Well, The University of Newcastle, Newcastle, NSW, Australia., Smigielski L; Department of Child and Adolescent Psychiatry, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland., Sugranyes G; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain., Suzuki M; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Takahashi T; Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Tamnes CK; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway., Theodoridou A; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Tomyshev AS; Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russian Federation., Uhlhaas PJ; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK., Værnes TG; Early Intervention in Psychosis Advisory Unit for South-East Norway, TIPS Sør-Øst, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., van Amelsvoort TA; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., van Erp TG; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA., Waltz JA; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA., Wenneberg C; Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Wood SJ; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.; Orygen, Melbourne, VIC, Australia.; School of Psychology, University of Birmingham, Birmingham, UK., Zhou JH; Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Center for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Hernaus D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Jalbrzikowski M; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA., Kahn RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Corcoran CM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, NY, USA., Frangou S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Djavad Mowafaghian Centre for Brain Health, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 18. Date of Electronic Publication: 2023 Jan 18. |
| DOI: | 10.1101/2023.01.17.523348 |
| Abstrakt: | Importance: The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in the majority of individuals at psychosis risk may be nested within the range observed in healthy individuals. Objective: To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high-risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder. Design Setting and Participants: Clinical, IQ and FreeSurfer-derived regional measures of cortical thickness (CT), cortical surface area (SA), and subcortical volume (SV) from 1,340 CHR-P individuals [47.09% female; mean age: 20.75 (4.74) years] and 1,237 healthy individuals [44.70% female; mean age: 22.32 (4.95) years] from 29 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. Main Outcomes and Measures: For each regional morphometric measure, z-scores were computed that index the degree of deviation from the normative means of that measure in a healthy reference population (N=37,407). Average deviation scores (ADS) for CT, SA, SV, and globally across all measures (G) were generated by averaging the respective regional z-scores. Regression analyses were used to quantify the association of deviation scores with clinical severity and cognition and two-proportion z-tests to identify case-control differences in the proportion of individuals with infranormal (z<-1.96) or supranormal (z>1.96) scores. Results: CHR-P and healthy individuals overlapped in the distributions of the observed values, regional z-scores, and all ADS vales. The proportion of CHR-P individuals with infranormal or supranormal values in any metric was low (<12%) and similar to that of healthy individuals. CHR-P individuals who converted to psychosis compared to those who did not convert had a higher percentage of infranormal values in temporal regions (5-7% vs 0.9-1.4%). In the CHR-P group, only the ADS Conclusions and Relevance: The study findings challenge the usefulness of macroscale neuromorphometric measures as diagnostic biomarkers of psychosis risk and suggest that such measures do not provide an adequate explanation for psychosis risk. |
| Databáze: | MEDLINE |
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