Novel amino-functionalized magnetic metal-organic framework/layered double hydroxide adsorbent for microfluidic solid phase extraction: Application for vitamin D 3 .

Autor: Bagheri N; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod 123, Oman., Al Lawati HAJ; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod 123, Oman. Electronic address: haiderl@squ.edu.om., Hassanzadeh J; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod 123, Oman., Al Lawati I; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod 123, Oman.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2023 May 01; Vol. 256, pp. 124272. Date of Electronic Publication: 2023 Jan 19.
DOI: 10.1016/j.talanta.2023.124272
Abstrakt: Vitamin D deficiency is highly prevalent worldwide, especially with limited sun exposure and sun avoidance. Thus, reliable monitoring of vitamin D levels in food and biological samples is vital for medicinal diagnosis. Herein, a potent method for the extraction and determination of vitamin D 3 is presented using a microchip-based solid-phase extraction (SPE) device followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) detection. A new magnetic adsorbent based on Fe 3 O 4 magnetic nanoparticles (MNPs) modified ZnFe layered double hydroxide (LDH)/2-aminoterephthalic acid-Zn 2+ metal-organic framework (IRMOF-3) composite (IRMOF-3@MLDH) was successfully synthesized and fixed inside a rectangular micro-column (4 × 2 × 12 mm). The porous structure and high surface area of IRMOF-3@MLDH provide abundant adsorbing sites and make it a potent SPE adsorbent, with an exceptional ability to retain vitamin D 3 . The adsorption isotherm showed that the composite was highly efficient at extracting vitamin D 3 with an extraction capacity of 126 mg g -1 . The designed extraction microchip simplified the SPE process, paving the way for automated SPE systems. The developed method presented a broad linear range of 5-2000 ng mL -1 , with a detection limit of 1.4 ng mL -1 . In comparison to conventional silica-based adsorbents, a higher sensitivity was obtained in the determination of vitamin D 3 using the IRMOF-3@MLDH adsorbent. The selectivity of the method was also satisfactory, enabling the measurement of vitamin D 3 in food and blood samples with high recovery values in the range from 95.2 to 101%. Thus, the newly developed adsorbent and method offer an efficient alternative to the commonly used C18-based approach.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: