The amphibian invitrome: Past, present, and future contributions to our understanding of amphibian immunity.

Autor: Douglas AJ; Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada., Todd LA; Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada., Katzenback BA; Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada. Electronic address: barb.katzenback@uwaterloo.ca.
Jazyk: angličtina
Zdroj: Developmental and comparative immunology [Dev Comp Immunol] 2023 May; Vol. 142, pp. 104644. Date of Electronic Publication: 2023 Jan 25.
DOI: 10.1016/j.dci.2023.104644
Abstrakt: Many amphibian populations are declining worldwide, and infectious diseases are a leading cause. Given the eminent threat infectious diseases pose to amphibian populations, there is a need to understand the host-pathogen-environment interactions that govern amphibian susceptibility to disease and mortality events. However, using animals in research raises an ethical dilemma, which is magnified by the alarming rates at which many amphibian populations are declining. Thus, in vitro study systems such as cell lines represent valuable tools for furthering our understanding of amphibian immune systems. In this review, we curate a list of the amphibian cell lines established to date (the amphibian invitrome), highlight how research using amphibian cell lines has advanced our understanding of the amphibian immune system, anti-ranaviral defence mechanisms, and Batrachochytrium dendrobatidis replication in host cells, and offer our perspective on how future use of amphibian cell lines can advance the field of amphibian immunology.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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