Narcolepsy secondary to anti-Ma2 encephalitis: two case reports.

Autor:	Brunet de Courssou JB; Neurology Department, Hôpital d'Instruction des Armées Percy, Clamart, France., Testard P; Sleep Disorders Unit, Hôpital Pitié-Salpêtrière, Paris, France., Sallansonnet-Froment M; Neurology Department, Hôpital d'Instruction des Armées Percy, Clamart, France., Brechemier ML; Neurology Department, Hôpital d'Instruction des Armées Percy, Clamart, France., Ricard D; Neurology Department, Hôpital d'Instruction des Armées Percy, Clamart, France., Psimaras D; Neurology Department, Onco-Neurology Service, Hôpital Pitié-Salpêtrière, Paris, France., Ferrand M; Neurology Department, Hôpital Central - CHRU de Nancy, Nancy, France., Maillet T; Internal Medicine Department, Centre Hospitalier de Mâcon, Mâcon, France., Depierre P; Neurology Department, Centre Hospitalier de Mâcon, Mâcon, France., Ohlmann C; Radiology Department, Hôpital d'Instruction des Armées Percy, Clamart, France., Capron J; Neurology Department, Hôpital Saint-Antoine, Paris, France., Arnulf I; Sleep Disorders Unit, Hôpital Pitié-Salpêtrière, Paris, France.; Sorbonne University, Paris, France., Gales A; Sleep Disorders Unit, Hôpital Pitié-Salpêtrière, Paris, France.
Jazyk:	angličtina
Zdroj:	Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2023 Apr 01; Vol. 19 (4), pp. 837-841.
DOI:	10.5664/jcsm.10448
Abstrakt:	Recent studies suggest that sleep disorders are present in two-thirds of patients with autoimmune encephalitis. In anti-Ma2 encephalitis, hypersomnia appears to be frequent. However, only few cases of type 1 narcolepsy have been reported to date with anti-Ma2 encephalitis. We report 2 new cases of patients with narcolepsy secondary to anti-Ma2 encephalitis. Patient 1, a 68-year-old man, had narcolepsy type 1, including sleep attacks, cataplexy, abnormal Multiple Sleep Latency Tests and hypocretin-1 deficiency (< 50 ng/L) in the cerebrospinal fluid (CSF), associated with a cerebellar syndrome. Anti-Ma2 antibodies were present in the serum and CSF and antivoltage-gated potassium channel antibodies in the serum. He benefited from a treatment with pitolisant. Patient 2, a 42-year-old man, had narcolepsy type 2, including hypersomnolence, no cataplexy, intermediate CSF levels of hypocretin-1 (138 ng/L), abnormal Multiple Sleep Latency Tests, and a limbic encephalitis presentation. Anti-Ma2 antibodies were present in the serum and CSF, and anti-Ma1 antibodies were in the CSF. For both, repeated polysomnographies were necessary to establish the precise diagnosis of central hypersomnia, emphasizing the importance of carrying out sleep investigations in a tertiary neurology center with sleep medicine expertise in patients with anti-Ma2 encephalitis. Citation: Brunet de Courssou J-B, Testard P, Sallansonnet-Froment M, et al. Narcolepsy secondary to anti-Ma2 encephalitis: two case reports. J Clin Sleep Med . 2023;19(4):837-841. (© 2023 American Academy of Sleep Medicine.)
Databáze:	MEDLINE
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