Pre-clinical efficacy of African medicinal plants used in the treatment of snakebite envenoming: A systematic review.

Autor: Bala AA; Department of Pharmacology, College of Medicine and Health Sciences, Federal University Dutse, Nigeria; Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria. Electronic address: auwal.bala@fud.edu.ng., Mohammed M; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Pulau Pinang, Malaysia; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna, Nigeria., Umar S; Department of Pharmacognosy and Herbal Medicine, Faculty of Pharmaceutical Sciences, College of Natural and Pharmaceutical Sciences, Bayero University Kano, Nigeria., Ungogo MA; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, 810107, Kaduna State, Nigeria; Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK., Al-Kassim Hassan M; Faculty of Pharmaceutical Sciences, Bayero University Kano - Nigeria, Nigeria., Abdussalam US; Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria., Ahmad MH; Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Capital City University, Kano State, Nigeria., Ishaq DU; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Science,Bayero University, Kano, Nigeria; Center for Mitochondrial Biology & Medicine, Xi'an Jiaotong University (XJTU), Xi'an, China., Mana D; Department of Community Medicine and Primary Healthcare, Bingham University, Abuja, Nigeria., Sha'aban A; School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4YS, UK., Jatau AI; School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia., Jibril M; Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria., Kurfi B; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Science,Bayero University, Kano, Nigeria., Raji I; Department of Pharmacology, College of Medicine and Health Sciences, Federal University Dutse, Nigeria., Ringim AS; Morgan State University, Patuxent Environmental and Aquatic Research Laboratory, Maryland, USA; Department of Biological Sciences, Federal University Dutse, Jigawa State, Nigeria., Gulma K; School of Global Health and Bioethics, Euclid University, Gambia., Malami S; Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria., Michael GC; Department of Family Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Chedi BAZ; Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria; Venom-Antivenom Research Project (VASP) and Nigeria- Snakebite Research and Intervention Centre(NSRIC), Nigeria.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2023 Mar 01; Vol. 224, pp. 107035. Date of Electronic Publication: 2023 Jan 24.
DOI: 10.1016/j.toxicon.2023.107035
Abstrakt: The World Health Organization has listed Snakebite Envenoming (SBE) as a priority neglected tropical disease, with a worldwide annual snakebite affecting 5.4 million people and injuring 2.7 million lives. In many parts of rural areas of Africa and Asia, medicinal plants have been used as alternatives to conventional antisnake venom (ASV) due in part to inaccessibility to hospitals. Systemic reviews (SR) of laboratory-based preclinical studies play an essential role in drug discovery. We conducted an SR to evaluate the relationship between interventional medicinal plants and their observed effects on venom-induced experiments. This SR was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The Modified collaborative approach to meta-analysis and review of animal data from experimental studies (CAMARADES) and SYRCLE's risk of bias tools were used to appraise the included studies. Data were searched online in Medline via PubMed, Embase via OVID, and Scopus. Studies reporting in vivo and in vitro pharmacological activities of African medicinal plants/extracts/constituents against venom-induced pathologies were identified and included for screening. Data from the included studies were extracted and synthesized. Ten studies reported statistically significant percentage protection (40-100%) of animals against venom-induced lethality compared with control groups that received no medicinal plant intervention. Sixteen studies reported significant effects (p ≤ 0.05) against venom-induced pathologies compared with the control group; these include hemolytic, histopathologic, necrotic, and anti-enzymatic effects. The plant family Fabaceae has the highest number of studies reporting its efficacy, followed by Annonaceae, Malvaceae, Combretaceae, Sterculiaceae, and Olacaceae. Some African medicinal plants are preclinically effective against venom-induced lethality, hematotoxicity, and cytotoxicity. The evidence was extracted from three in vitro studies, nine in vivo studies, and five studies that combined both in vivo and in vitro models. The effective plants belong to the Fabaceae family, followed by Malvaceae, and Annonaceae.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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