Radiologic and histopathologic features of hydrogel sealant after lung resection in participants of a prospective randomized clinical trial.

Autor: Moussa AM; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: moussaa@mskcc.org., Hui Y; Department of Pathology, Division of Thoracic Pathology, Memorial Sloan Kettering Cancer Center, United States of America., Araujo Filho JA; Department of Radiology, Division of Thoracic Imaging, Memorial Sloan Kettering Cancer Center, United States of America., Muallem N; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America., Li D; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: lid1@mskcc.org., Jihad M; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: jihadm@mskcc.org., Hsu M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: hsum1@mskcc.org., Moskowitz CS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: moskowc1@mskcc.org., Travis WD; Department of Pathology, Division of Thoracic Pathology, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: travisw@mskcc.org., Solomon SB; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: solomons@mskcc.org., Ginsberg MS; Department of Radiology, Division of Thoracic Imaging, Memorial Sloan Kettering Cancer Center, United States of America. Electronic address: ginsberm@mskcc.org., Maybody M; Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America.
Jazyk: angličtina
Zdroj: Clinical imaging [Clin Imaging] 2023 Mar; Vol. 95, pp. 92-96. Date of Electronic Publication: 2022 Dec 27.
DOI: 10.1016/j.clinimag.2022.12.008
Abstrakt: Purpose: To summarize imaging and histopathologic characteristics of hydrogel sealant (plug) in lung parenchyma and assess their correlation with time since deployment of sealant.
Materials and Methods: Among a total of 208 participants randomized to the hydrogel sealant arm of a lung biopsy prospective randomized clinical trial, 51 underwent resection of the biopsied lesion. In 34 participants sealant material was present on histopathologic sections (n = 22), or they had cross-sectional imaging of chest between biopsy and resection (n = 23) or they had both imaging and histopathology (n = 11). Histopathologic and imaging findings were described. The association of these findings with time since sealant deployment was evaluated using the Wilcoxon rank sum test.
Results: The mean time since sealant deployment for histopathology was 45.7 days (median 36, range 14-181) and for imaging studies was 99 days (median 32, range 4-527). The sealant was infiltrated by inflammatory cells in 20 (91%) participants. The main general histopathologic pattern of sealant was foamy in 12 (57%) and mesh in 8 (38%) participants. Imaging appearance of sealant was serpiginous in 18 (60%), linear in 10 (33%) or lobulated in 2 (6.7%) participants. In 2 participants the sealant was hypermetabolic with no histopathologic evidence of tumor. No correlation was found between time since sealant deployment and imaging or histopathologic appearances.
Conclusion: Hydrogel sealant appears as a serpiginous, linear, or lobulated opacity on cross-sectional imaging which can be metabolically active. It is associated with an inflammatory reaction with a foamy or mesh general pattern on histopathological assessment. No correlation was found between time since sealant deployment and imaging or histopathologic appearances.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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