Comparison of mean diffusivity, R2* relaxation rate and morphometric biomarkers for the clinical differentiation of parkinsonism.

Autor: Chougar L; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France; ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; ICM, Team 'Movement Investigations and Therapeutics' (MOV'IT), Paris, France; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France. Electronic address: lydia.chougar@aphp.fr., Lejeune FX; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France; ICM, Data and Analysis Core, Paris, France., Faouzi J; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, F-75013, Paris, France., Morino B; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France., Faucher A; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, Université PSL, Paris, France; Service de Neurologie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine-Saint-Denis, APHP, Bobigny, France., Hoyek N; Department of Radiology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon., Grabli D; Clinique des mouvements anormaux, Département de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France; ICM, Centre d'Investigation Clinique Neurosciences, Paris, France., Cormier F; Clinique des mouvements anormaux, Département de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France; ICM, Centre d'Investigation Clinique Neurosciences, Paris, France., Vidailhet M; ICM, Team 'Movement Investigations and Therapeutics' (MOV'IT), Paris, France; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France; Clinique des mouvements anormaux, Département de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France; ICM, Centre d'Investigation Clinique Neurosciences, Paris, France., Corvol JC; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France; Clinique des mouvements anormaux, Département de Neurologie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France; ICM, Centre d'Investigation Clinique Neurosciences, Paris, France., Colliot O; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, F-75013, Paris, France; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, F-75013, Paris, France., Degos B; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, Université PSL, Paris, France; Service de Neurologie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine-Saint-Denis, APHP, Bobigny, France., Lehéricy S; ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; ICM, Team 'Movement Investigations and Therapeutics' (MOV'IT), Paris, France; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, F-75013, Paris, France.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2023 Mar; Vol. 108, pp. 105287. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1016/j.parkreldis.2023.105287
Abstrakt: Introduction: Quantitative biomarkers for clinical differentiation of parkinsonian syndromes are still lacking. Our aim was to evaluate the value of combining clinically feasible manual measurements of R2* relaxation rates and mean diffusivity (MD) in subcortical regions and brainstem morphometric measurements to improve the discrimination of parkinsonian syndromes.
Methods: Twenty-two healthy controls (HC), 25 patients with Parkinson's disease (PD), 19 with progressive supranuclear palsy (PSP) and 27 with multiple system atrophy (MSA, 21 with the parkinsonian variant -MSAp, 6 with the cerebellar variant -MSAc) were recruited. R2*, MD measurements and morphometric biomarkers including the midbrain to pons area ratio and the Magnetic Resonance Parkinsonism Index (MRPI) were compared between groups and their diagnostic performances were assessed.
Results: Morphometric biomarkers discriminated better patients with PSP (ratio: AUC 0.89, MRPI: AUC 0.89) and MSAc (ratio: AUC 0.82, MRPI: AUC 0.75) from other groups. R2* and MD measurements in the posterior putamen performed better in separating patients with MSAp from PD (R2*: AUC 0.89; MD: AUC 0.89). For the three-class classification "MSA vs PD vs PSP", the combination of MD and R2* measurements in the posterior putamen with morphometric biomarkers (AUC: 0.841) outperformed each marker separately. At the individual-level, there were seven discordances between imaging-based prediction and clinical diagnosis involving MSA. Using the new Movement Disorder Society criteria for the diagnosis of MSA, three of these seven patients were clinically reclassified as predicted by quantitative imaging.
Conclusion: Combining R2* and MD measurements in the posterior putamen with morphometric biomarkers improves the discrimination of parkinsonism.
Competing Interests: Declaration of competing interest No conflicts of interest related to the present study. Competing financial interests unrelated to the present work: Jean-Christophe Corvol has served in scientific advisory boards for Biogen, Denali, Ever Pharma, Isdorsia, Prevail Therapeutics, and UCB; and has received grants from Sanofi, the Michael J Fox Foundation, ANR, France Parkinson, the French Ministry of Health. Olivier Colliot received consulting fees from AskBio (2020), received fees for writing a lay audience short paper from Expression Santé (2019), received speaker fees for a lay audience presentation from Palais de la découverte (2017). His laboratory received grants (paid to the institution) from Air Liquide Medical Systems (2011–2016) and Qynapse (2017–present). Members from his laboratory have cosupervised a PhD thesis with myBrainTechnologies (2016–present). Colliot's spouse is an employee of myBrainTechnologies (2015–present). Colliot has submitted a patent to the International Bureau of the World Intellectual Property Organization (PCT/IB2016/052699 3, J.-B. Schiratti, S. Allassonniere, O. Colliot, S. Durrleman, “A method for determining the temporal progression of a biological phenomenon and associated methods and devices,” 2016). Bertrand Degos received research support grants from Fondation de France, Inserm, and ANR; speech honoraria from Ipsen, Merz Pharma, and Orkyn; and received travel funding from Merz Pharma, Elivie, and Orkyn. Stéphane Lehéricy received grants from ‘Investissements d'avenir’ (gran t numbers ANR-10-IAIHU -06 and AN R-11-INBS-0006) and Biogen Inc.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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