Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?-a case report.

Autor:	Ribeiro MCO; Gastroenterology Division, Department of Internal Medicine, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Botucatu, Brazil., Lemos JVB; Hospital Estadual Bauru, Fundação para o Desenvolvimento Médico e Hospitalar (FAMESP), Bauru, Brazil., de Toledo Moraes MP; Department of Pathology, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Botucatu, Brazil., Oliver FA; Department of Radiology, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Botucatu, Brazil., Alvarez M; Center of Medical Physics and Radiation Protection, Clinical Hospital at Botucatu School of Medicine-HC-FMB, Botucatu, Brazil., Silva GF; Gastroenterology Division, Department of Internal Medicine, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Botucatu, Brazil., Qi X; Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang, China., Romeiro FG; Gastroenterology Division, Department of Internal Medicine, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Botucatu, Brazil.
Jazyk:	angličtina
Zdroj:	Translational gastroenterology and hepatology [Transl Gastroenterol Hepatol] 2023 Jan 25; Vol. 8, pp. 12. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).
DOI:	10.21037/tgh-22-48
Abstrakt:	Background: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare neoplastic disease of varied presentation and unspecific radiological signs in the early stages. The diagnostic delay can lead to metastatic disease, thus increasing the tumor burden and reducing the treatment options. HEHE is usually deemed a slow-growing tumor, but its speed of growth is poorly reported and still unknown. Case Description: In this case report, we documented a HEHE diagnosed in a young woman who had complaints of abdominal pain, weight loss and bloating for a long time. The typical findings observed in histological studies were not promptly recognized in the histological analyzes, even after two laparoscopic-guided liver biopsies, delaying the diagnosis until extrahepatic tumor spreading. Findings observed in computed tomography, magnetic resonance imaging and histological studies are presented. The coalescence of nodules and the rising of giant masses, occupying large parts of the liver in a specific time span, were registered and quantified. As opposed to prior reports, the results show that hepatic HEHE can grow rapidly, reinforcing the need of early diagnosis, thus avoiding the complications presented herein. Conclusions: The findings observed via radiological and histological imaging that could have avoided the diagnosis delay are depicted and discussed, showing that HEHE can rise faster than previously documented. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-22-48/coif). FGR reports that the study was funded by São Paulo Research Cientific Foundation (FAPESP; Grant No. 2017/25592-9), but only the Institution received the payments. None of them was done for the researcher. The researcher has received funding from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The funding is a scholarship for researchers according to their scientific production. The other authors have no conflicts of interest to declare. (2023 Translational Gastroenterology and Hepatology. All rights reserved.)
Databáze:	MEDLINE
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