Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy.

Autor:	Reiss Z; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Rob F; Department of Dermatovenerology, Second Faculty of Medicine, Charles University, University Hospital Bulovka, Prague, Czechia., Kolar M; IBD Clinical and Research Centre ISCARE a.s., Prague, Czechia., Schierova D; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Kreisinger J; Department of Zoology, Faculty of Science, Charles University, Prague, Czechia., Jackova Z; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Roubalova R; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Coufal S; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Mihula M; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Thon T; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Bajer L; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.; Department of Gastroenterology and Hepatology, Institute of Clinical and Experimental Medicine, Prague, Czechia., Novakova M; Department of Dermatovenerology, Second Faculty of Medicine, Charles University, University Hospital Bulovka, Prague, Czechia., Vasatko M; IBD Clinical and Research Centre ISCARE a.s., Prague, Czechia., Kostovcikova K; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Galanova N; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Lukas M; IBD Clinical and Research Centre ISCARE a.s., Prague, Czechia.; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czechia., Kverka M; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Tresnak Hercogova J; Department of Dermatovenerology, Second Faculty of Medicine, Charles University, University Hospital Bulovka, Prague, Czechia.; Prof. Hercogova Dermatology, Prague, Czechia., Tlaskalova-Hogenova H; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia., Jiraskova Zakostelska Z; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Jan 10; Vol. 12, pp. 1064537. Date of Electronic Publication: 2023 Jan 10 (Print Publication: 2022).
DOI:	10.3389/fcimb.2022.1064537
Abstrakt:	Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. Inhibitors of TNF have been successful in IBD treatment, but up to a quarter of patients suffer from unpredictable skin adverse events (SkAE). For this purpose, we analyzed temporal dynamics of skin microbiota and serum markers of inflammation and epithelial barrier integrity during anti-TNF therapy and SkAE manifestation in IBD patients. We observed that the skin microbiota signature of IBD patients differs markedly from healthy subjects. In particular, the skin microbiota of CD patients differs significantly from that of UC patients and healthy subjects, mainly in the retroauricular crease. In addition, we showed that anti-TNF-related SkAE are associated with specific shifts in skin microbiota profile and with a decrease in serum levels of L-FABP and I-FABP in IBD patients. For the first time, we showed that shifts in microbial composition in IBD patients are not limited to the gut and that skin microbiota and serum markers of the epithelium barrier may be suitable markers of SkAE during anti-TNF therapy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Reiss, Rob, Kolar, Schierova, Kreisinger, Jackova, Roubalova, Coufal, Mihula, Thon, Bajer, Novakova, Vasatko, Kostovcikova, Galanova, Lukas, Kverka, Tresnak Hercogova, Tlaskalova-Hogenova and Jiraskova Zakostelska.)
Databáze:	MEDLINE
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