The role of baseline insomnia in moderating the hypnotic properties of quetiapine.

Autor: Krouse RA; Coatesville Veterans Affairs Medical Center, Coatesville, PA 19320, USA; School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: ryan.krouse@va.gov., Morales KH; Department of Biostatistics and Epidemiology, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: knashawn@pennmedicine.upenn.edu., Kampman KM; Department of Psychiatry, Cpl. Michael J. Crescenz VA Medical Center, PA 19104, USA; Department of Psychiatry, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: kampman@pennmedicine.upenn.edu., Chakravorty S; Department of Psychiatry, Cpl. Michael J. Crescenz VA Medical Center, PA 19104, USA; Department of Psychiatry, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: Subhajit.Chakravorty@pennmedicine.upenn.edu.
Jazyk: angličtina
Zdroj: Addictive behaviors [Addict Behav] 2023 May; Vol. 140, pp. 107622. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1016/j.addbeh.2023.107622
Abstrakt: Introduction: The primary aim of this study was to investigate the effect of quetiapine on insomnia and alcohol craving (craving) in subjects with co-occurring insomnia and AUD.
Methods: Insomnia was assessed with the Insomnia Severity Index (ISI) and craving with the Penn Alcohol Craving Scale (PACS, primary) and Obsessive-Compulsive Drinking Scale (OCDS, secondary). A multivariable model adjusted for covariates (N = 123) evaluated the relationship between craving (PACS and OCDS total scores) and insomnia (ISI total score). To simultaneously assess the effects of treatment arm allocation and insomnia status, subjects (N = 115) were stratified into 4 groups, quetiapine-insomnia(N = 38), quetiapine-No insomnia(N = 19), placebo-insomnia(N = 38), and placebo-No insomnia(N = 20). Linear mixed-effects regression models adjusted for covariates compared the trajectories of ISI, PACS, and OCDS total scores across 12 weeks of treatment and at post-treatment follow-up at week 24, between the four groups.
Results: The ISI total score was positively associated with the PACS (p = 0.006) and OCDS (p = 0.001) total scores in the multivariable models. In the longitudinal analysis, when compared to the three other groups, subjects with insomnia treated with quetiapine showed a marked reduction in their insomnia scores with a return of insomnia after stopping treatment. There was no significant difference between the groups for the PACS and OCDS total score trajectories.
Discussion: Although craving is associated with insomnia, treatment with quetiapine may improve insomnia but not craving in patients with co-occurring AUD and insomnia.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: