Pharmacokinetic profiles of the two major active metabolites of metamizole, 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), after intravenous injection in cats.

Autor: de Paula VV; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil. Electronic address: valeria@ufersa.edu.br., Araújo-Silva G; Universidade do Estado do Amapá, Avenida Presidente Vargas, Centro, Macapá, AP 68.900-070, Brazil., Fernandes NS; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., Mouta AN; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., Nunes TL; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., de Paiva ALC; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., de Macêdo LB; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., Arcoverde KN; Department of Animal Science, Universidade Federal Rural do Semi-Árido, 572, Avenida Francisco Mota, 572 - Bairro Costa e Silva, Mossoró, RN 59625-900, Brazil., Urizar JTP; Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Salvador Nava, 6, San Luis do Potosí, Mexico.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2023 Feb; Vol. 155, pp. 156-160. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1016/j.rvsc.2023.01.007
Abstrakt: This study aimed to determine the pharmacokinetic profile of two active metabolites of metamizole (dipyrone), N-methyl-4-aminoanthypyrine (MAA) and 4-aminoanthypyrine (AA), after intravenous administration in cats. Eight healthy mixed-breed cats were intravenously administered metamizole (25 mg/kg). Blood samples were collected at predetermined time points for up to 48 h after administration. Information on behavioral changes in the animals and adverse effects was collected. Plasma aliquots were processed and analyzed using the ultra-performance liquid chromatography tandem mass spectrometry technique. A validated UPLC-MS/MS method was used to characterize the pharmacokinetics of MAA and AA. Salivation was identified as an adverse clinical sign. The mean maximal plasma concentrations of MAA and AA were 29.31 ± 24.57 μg/mL and 1.69 ± 0.36 μg/mL, with half-lives of around 4.98 and 14 h, respectively. The area under the plasma concentration curve values were 28.54 ± 11.33 and 49.54 ± 11.38 h*μg/mL for MAA and AA, respectively. The plasma concentration of MAA was detectable for up to 24 h and was smaller than AA. AA was detectable for >48 h. Results suggest that metamizole is converted into active metabolites in cats. Further PK/PD and safety studies should be performed before defining the dose or administration intervals for clinical use.
Competing Interests: Declaration of Competing Interest The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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