Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.

Autor: Lee M; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Joehanes R; Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA 01702, USA., McCartney DL; Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK., Kho M; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Hüls A; Department of Epidemiology & Gangarosa, Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA., Wyss AB; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Liu C; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02215, USA.; Framingham Heart Study, Boston University, Framingham, MA 01702, USA., Walker RM; Centre for Clinical Brain Science, Chancellor's Building, 49 Little France Crescent, Edinburgh Bioquarter, Edinburgh, UK.; School of Psychology, University of Exeter, Exeter, UK., R Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Wingo TS; Department of Neurology & Human Genetics, Emory University, Atlanta, GA 30322, USA., Burkholder A; Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Ma J; Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA 01702, USA., Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK., Wingo AP; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA 30322, USA., Huan T; Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA 01702, USA.; Department of Ophthalmology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Sikdar S; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.; Department of Mathematics & Statistics, Old Dominion University, Norfolk, VA 23529, USA., Keshawarz A; Framingham Heart Study, Framingham, MA 01702, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Evans KL; Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK., Levy D; Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA 01702, USA., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Jazyk: angličtina
Zdroj: Epigenomics [Epigenomics] 2022 Dec; Vol. 14 (23), pp. 1479-1492. Date of Electronic Publication: 2023 Jan 26.
DOI: 10.2217/epi-2022-0353
Abstrakt: Aim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: KIAA0226 , CPLX2 , TDRP , RNF38 , TTC23 and GPR179 . Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. Conclusion: This study identified DNA methylation related to opioid medication use in general populations. The results could inform the development of blood methylation biomarkers of opioid use.
Databáze: MEDLINE