THE INCREASED PLASMA LEVELS OF INTERMEDIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.
| Autor: | Liu F; Civil Aviation General Hospital, Department of Endocrinology, Beijing, China., Duan JT; Civil Aviation General Hospital, Department of Endocrinology, Beijing, China., Teng X; Hebei Medical University, Department of Physiology, Shijiazhuang, China.; Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Shijiazhuang, China., Peng DQ; Civil Aviation General Hospital, Department of Endocrinology, Beijing, China. |
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| Jazyk: | angličtina |
| Zdroj: | Acta endocrinologica (Bucharest, Romania : 2005) [Acta Endocrinol (Buchar)] 2022 Jul-Sep; Vol. 18 (3), pp. 271-277. |
| DOI: | 10.4183/aeb.2022.271 |
| Abstrakt: | Context: Intermedin (IMD) is the member of calcitonin gene-related peptide family, and tightly associated with type 2 diabetes mellitus (T2DM). The change of plasma IMD levels in T2DM is still unknown. Objective: We aimed to investigate the plasma levels of IMD in patients with T2DM. Design: Fortyone patients with T2DM who were hospitalized in the endocrinology department of Civil Aviation General Hospital from January 2012 to June 2015 were enrolled, and 44 volunteers were selected as the control group. Subjects and Methods: Plasma level of IMD was detected by ELISA. Diagnostic value of IMD was analyzed by area under the receiver operating characteristic (ROC) curve (AUC). Results: The plasma level of IMD in T2DM group was higher than that in the healthy control group, whereas smoking or cardiovascular complications did no influence the IMD levels. IMD levels were correlated with BMI, DBP, triglyceride, uric acid, urea nitrogen, fasting and 2 hours postprandial blood glucose, and HbA1C. The greatest value of AUC for IMD was only 58.73%. Conclusions: Although plasma levels of IMD were increased in patients with T2DM, the very low diagnostic value of IMD for T2DM might not be used for the disease diagnosis. Competing Interests: The authors declare that they have no conflict of interest. (©2022 Acta Endocrinologica (Buc).) |
| Databáze: | MEDLINE |
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