Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri ) extracts on human macrophages and chemical characterization.

Autor:	Nicolas M; Département de Chimie, Université Côte d'Azur, Nice, France., Lasalo M; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia., Chow S; Neuroinflammation Group, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Antheaume C; Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg, Strasbourg, France., Huet K; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia., Hnawia E; PHARMADEV, UMR152, Institut de Recherche pour le Développement (IRD), Noumea Center, Noumea, New Caledonia., Guillemin GJ; Neuroinflammation Group, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Nour M; Institut des Sciences Exactes et Appliqués (ISEA), EA7484, Université de Nouvelle-Calédonie, Noumea, New Caledonia., Matsui M; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia.; Institut des Sciences Exactes et Appliqués (ISEA), EA7484, Université de Nouvelle-Calédonie, Noumea, New Caledonia.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2023 Jan 09; Vol. 13, pp. 1081310. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.1081310
Abstrakt:	Introduction: Formerly named Plectranthus forsteri , Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1 ), coleon U-quinone ( 2 ), 8α,9α-epoxycoleon U-quinone ( 3 ), horminone or 7α-hydroxyroyleanone ( 4 ), 6β,7α-dihydroxyroyleanone ( 5 ), 7α-acetoxy-6β-hydroxyroyleanone ( 6 ) and 7α-formyloxy-6β-hydroxyroyleanone ( 7 ). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Nicolas, Lasalo, Chow, Antheaume, Huet, Hnawia, Guillemin, Nour and Matsui.)
Databáze:	MEDLINE
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