Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis.

Autor:	Thomas K; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Lazarini A; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Kaltsonoudis E; Rheumatology Clinic, University of Ioannina, Ioannina, Greece., Voulgari PV; Rheumatology Clinic, University of Ioannina, Ioannina, Greece., Drosos AA; Rheumatology Clinic, University of Ioannina, Ioannina, Greece., Repa A; Department of Clinical Immunology and Allergy, University of Crete, Heraklion, Greece., Sali AMI; Department of Clinical Immunology and Allergy, University of Crete, Heraklion, Greece., Sidiropoulos P; Department of Clinical Immunology and Allergy, University of Crete, Heraklion, Greece., Tsatsani P; Rheumatology Unit, KAT Hospital, Athens, Greece., Gazi S; Rheumatology Unit, KAT Hospital, Athens, Greece., Fragkiadaki K; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Tektonidou MG; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Sfikakis PP; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Katsimbri P; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Boumpas D; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Argyriou E; Rheumatology Unit, Sismanoglio Hospital, Athens, Greece., Boki KA; Rheumatology Unit, Sismanoglio Hospital, Athens, Greece., Karagianni K; Department of Rheumatology, University of Thessaly, Larissa, Greece., Katsiari C; Department of Rheumatology, University of Thessaly, Larissa, Greece., Evangelatos G; Rheumatology Unit, NIMTS Hospital, Athens, Greece., Iliopoulos A; Rheumatology Unit, NIMTS Hospital, Athens, Greece., Grika EP; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Vlachoyiannopoulos PG; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Dimitroulas T; 4th Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Garyfallos A; 4th Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Melissaropoulos K; Rheumatology Unit, Agios Andreas Hospital, Patras, Greece., Georgiou P; Rheumatology Unit, Agios Andreas Hospital, Patras, Greece., Georganas C; Private Practitioner, Athens, Greece., Vounotrypidis P; Private Practitioner, Thessaloniki, Greece., Ntelis K; Private Practitioner, Kalamata, Greece., Areti M; Private Practitioner, Leivadia, Greece., Kitas GD; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Hygeia Hospital, Athens, Greece., Vassilopoulos D; Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2023 Jan 09; Vol. 9, pp. 1039464. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.1039464
Abstrakt:	Introduction: Patients with rheumatoid arthritis (RA) are at increased risk for serious infections. Pneumococcal vaccination is among the most important preventive measures, however, vaccine uptake is suboptimal. We explored the rate and factors associated with pneumococcal vaccination in a contemporary RA cohort. Materials and Methods: Multi-center, prospective, RA cohort study in Greece. Patient and disease characteristics and influenza and pneumococcal vaccinations were documented at baseline and 3 years later. Results: One thousand six hundred and ninety-seven patients were included and 34.5% had already received at least one pneumococcal vaccine at baseline. Among 1,111 non-vaccinated patients, 40.1% received pneumococcal vaccination during follow-up, increasing the vaccine coverage to 60.8%. By multivariate analysis, positive predictors for pneumococcal vaccination included prescription of influenza vaccine (OR = 33.35, 95% CI: 18.58-59.85), history of cancer (OR = 2.35, 95% CI: 1.09-5.06), bDMARD use (OR = 1.85, 95% CI: 1.29-2.65), seropositivity (OR = 1.47, 95% CI: 1.05-2.05), and high disease activity (DAS28-ESR, OR = 1.33, 95% CI: 1.17-1.51). Male sex (OR = 0.65, 95% CI: 0.43-0.99) was a negative predictor for pneumococcal vaccination during follow-up. Discussion: Despite increasing rates of pneumococcal vaccine coverage, 40% of RA patients remain unvaccinated. Severe disease, bDMARD use, comorbidities, and more importantly flu vaccination were the most significant factors associated with pneumococcal vaccination, emphasizing the currently unmet need for cultivating a "vaccination culture" in RA patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Thomas, Lazarini, Kaltsonoudis, Voulgari, Drosos, Repa, Sali, Sidiropoulos, Tsatsani, Gazi, Fragkiadaki, Tektonidou, Sfikakis, Katsimbri, Boumpas, Argyriou, Boki, Karagianni, Katsiari, Evangelatos, Iliopoulos, Grika, Vlachoyiannopoulos, Dimitroulas, Garyfallos, Melissaropoulos, Georgiou, Georganas, Vounotrypidis, Ntelis, Areti, Kitas and Vassilopoulos.)
Databáze:	MEDLINE
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