Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross-sectional study.

Autor: Ofori EK; Department of Chemical Pathology University of Ghana Medical School Accra Ghana., Adekena CN; Department of Chemical Pathology University of Ghana Medical School Accra Ghana.; University of Ghana Medical Center Accra Ghana., Boima V; Department of Medicine and Therapeutics University of Ghana Medical School Accra Ghana., Asare-Anane H; Department of Chemical Pathology University of Ghana Medical School Accra Ghana., Yorke E; Department of Medicine and Therapeutics University of Ghana Medical School Accra Ghana., Nyarko ENY; Department of Chemical Pathology University of Ghana Medical School Accra Ghana., Mohammed BN; Department of Chemical Pathology University of Ghana Medical School Accra Ghana., Quansah E; University of Ghana Medical Center Accra Ghana., Jayasinghe SU; School of Health Sciences University of Tasmania Hobart Tasmania Australia., Amanquah SD; Department of Chemical Pathology University of Ghana Medical School Accra Ghana.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2023 Jan 19; Vol. 6 (1), pp. e1053. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
DOI: 10.1002/hsr2.1053
Abstrakt: Background and Aim: Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD-related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant.
Methods: An observational cross-sectional study involving a total of 108 participants (72 CKD patients with HHD and 36 healthy controls). Their demographic and anthropometric information was collected using a standardized questionnaire. Certain clinical measures such as blood pressure and body mass index (BMI) were assessed. Fasting blood samples were analyzed for levels of plasma glucose (FPG), lipids, creatinine, and leptin. Data were analyzed with SPSS v23.
Results: Leptin, FPG, creatinine and triglyceride levels were all significantly higher in CKD patients with HHD compared to controls ( p  < 0.01 for all). Furthermore, advanced CKD status (being in stage 5), having a 6-year diagnosis of HHD, being female, having a higher BMI, and elevation in levels of HDL and FPG contributed significantly to the variance in serum leptin levels in the case group ( β  = 0.37, 0.22, 0.19, 0.18, 0.27, 0.28; p  < 0.05 for all). In the control group, the female gender had the biggest unique effect on circulating leptin levels, followed by BMI and eGFR ( β  = 0.71, 0.34, -0.22; p  < 0.01 for all).
Conclusion: Patients with CKD who also had HHD reported considerably higher circulating leptin levels. Significantly higher blood leptin levels were shown to be associated with CKD stage 5 in the case group. These results are consistent with the role of leptin in the metabolic complexity seen in CKD patients. There needs to be more research into treatments that aim to lower leptin levels in CKD patients with HHD.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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