Electrophysiologically distinct bed nucleus of the stria terminalis projections to the ventral tegmental area in mice.

Autor:	Miura Y; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, United States.; Program in Biology, Graduate Center of the City University of New York, New York, NY, United States., Shanley MR; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, United States.; Program in Biology, Graduate Center of the City University of New York, New York, NY, United States., Urbaez A; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, United States., Friedman AK; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, United States.; Program in Biology, Graduate Center of the City University of New York, New York, NY, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neural circuits [Front Neural Circuits] 2023 Jan 09; Vol. 16, pp. 1081099. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022).
DOI:	10.3389/fncir.2022.1081099
Abstrakt:	The bed nucleus of the stria terminalis (BNST) is a highly heterogeneous limbic forebrain structure that serves as a relay connecting autonomic, neuroendocrine and behavioral function. It can be divided into over 16 individual subregions with distinct neuronal subpopulations based on receptors, transmitters, and neuropeptides. Specifically, the BNST projection to the ventral tegmental area (VTA), the dopamine hub of the brain, has been shown to have a crucial role in the stress response. However, in mice there is a lack of unbiased data on the functional diversity of this sub-population which serves as an upstream input to the VTA. The dopaminergic neurons in the VTA modify their ion channel activity and intrinsic membrane properties to adapt to stress in part from inputs from BNST projections. Therefore, we aimed to perform a multi-component characterization of the functional diversity of the BNST-VTA pathway. We studied the passive and active electrophysiological properties of virally identified population of BNST neurons that project to the VTA. We used a comprehensive series of in vitro recordings of electrophysiological variables and performed hierarchical clustering to determine the functional diversity of the projection neurons in the BNST-VTA pathway. Our study revealed four subpopulations in the BNST-VTA pathway, all of which differ in their activation profiles and likely have distinct inputs and function in the VTA. Our results will help resolve the discord in interpretation of the various roles of this electrophysiologically diverse projection and builds a foundation for understanding how the different neuronal types integrate signals. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Miura, Shanley, Urbaez and Friedman.)
Databáze:	MEDLINE
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