Multiresistant Candida Endophthalmitis Treated with Intravitreal Caspofungin: A Case Report.
| Autor: | Garrido-Marin M; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Kirkegaard Biosca E; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Boixadera A; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Fischer Fernandez R; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Sánchez Vela L; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Pardo Aranda A; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., García-Arumí J; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Distefano L; Ophthalmology Department, Vall d'Hebron University Hospital, Barcelona, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Aug; Vol. 32 (6), pp. 858-862. Date of Electronic Publication: 2023 Jan 25. |
| DOI: | 10.1080/09273948.2023.2168701 |
| Abstrakt: | Background: Candida endophthalmitis is a severe complication of candidemia. Currently, the recommended treatment of fungal endophthalmitis is a combination of intravitreal and systemic antifungal drugs, and in some cases vitrectomy is also required. Intravitreal therapies that are commonly used are amphotericin B and voriconazole, although recently the use of intravitreal caspofungin has been described in a few case reports. However, clinical experience with intravitreal caspofungin is still limited. Case Presentation: We report a case of bilateral candida tropicalis endophthalmitis, initially managed with repeated 100 μg/0.1 ml caspofungin intravitreal injections and posteriorly treated with pars plana vitrectomy in both eyes. Conclusions: Intravitreal caspofungin could be a safe intravitreal alternative to habitual antimycotic drugs in cases with resistant candida endophthalmitis. Abbreviations: Intensive Care Unit (ICU); Best-Corrected Visual Acuity (BCVA). |
| Databáze: | MEDLINE |
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