SARS-CoV-2 variants-associated outbreaks of COVID-19 in a tertiary institution, North-Central Nigeria: Implications for epidemic control.

Autor: Adeyemi OO; Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Molecular Diagnostic and Research Laboratory, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Ndodo ND; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Sulaiman MK; Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Molecular Diagnostic and Research Laboratory, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Ayansola OT; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Buhari OIN; Department of Behavioural Sciences, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Akanbi OA; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Bolarinwa OA; Department of Epidemiology and Community Health, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Chukwu C; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Joel IY; Molecular Diagnostic and Research Laboratory, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Omoare AA; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Wahab KW; Department of Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Obiekea C; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Buhari MO; Department of Pathology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Ahumibe A; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Kolawole CF; Health Services, University of Ilorin, Ilorin, Nigeria., Okoi C; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Omotesho OB; Health Services, University of Ilorin, Ilorin, Nigeria., Mba N; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Adeniyi O; Health Services, University of Ilorin, Ilorin, Nigeria., Babatunde O; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Akintunde N; Health Services, University of Ilorin, Ilorin, Nigeria., Ayinla G; Health Services, University of Ilorin, Ilorin, Nigeria., Akande OW; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria., Odunola RA; Health Services, University of Ilorin, Ilorin, Nigeria., Saka MJ; Department of Epidemiology and Community Health, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Musa OI; Department of Epidemiology and Community Health, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Durotoye IA; Department of Haematology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria., Ihekweazu C; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria.; Office of the Director General, Nigeria Centre for Disease Control, Abuja, Nigeria., Adetifa IM; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria.; Office of the Director General, Nigeria Centre for Disease Control, Abuja, Nigeria., Fadeyi A; Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.; Molecular Diagnostic and Research Laboratory, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Jan 25; Vol. 18 (1), pp. e0280756. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0280756
Abstrakt: The COVID-19 global pandemic is being driven by evolving SARS-CoV-2 variants with consequential implications on virus transmissibility, host immunity, and disease severity. Continuous molecular and genomic surveillance of the SARS-CoV-2 variants is therefore necessary for public health interventions toward the management of the pandemic. This study is a retrospective analysis of COVID-19 cases reported in a Nigerian tertiary institution from July to December 2021. In total, 705 suspected COVID-19 cases that comprised 547 students and 158 non-students were investigated by real time PCR (RT-PCR); of which 372 (~52.8%) tested positive for COVID-19. Using a set of selection criteria, 74 (~19.9%) COVID-19 positive samples were selected for next generation sequencing. Data showed that there were two outbreaks of COVID-19 within the university community over the study period, during which more females (56.8%) tested positive than males (47.8%) (p<0.05). Clinical data together with phylogenetic analysis suggested community transmission of SARS-CoV-2 through mostly asymptomatic and/or pre-symptomatic individuals. Confirmed COVID-19 cases were mostly mild, however, SARS-CoV-2 delta (77%) and omicron (4.1%) variants were implicated as major drivers of respective waves of infections during the study period. This study highlights the importance of integrated surveillance of communicable disease during outbreaks.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Adeyemi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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