Efficacy of multiple Biomarkers: NGAL, KIM1, Cystatin C and IL18 in predicting pregnancy related acute kidney injury.

Autor:	Naqvi R; Rubina Naqvi, Dept. of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan., Hossain N; Nazli Hossain, Dept. of Obstetrics and Gynecology, Unit II, Ruth Pfau KM Civil Hospital, Karachi. 74200. Pakistan., Butt S; Sofia Butt, Dept. of Obstetrics and Gynecology, Unit II, Ruth Pfau KM Civil Hospital, Karachi. 74200. Pakistan., Bhellar Z; Zeenat Bhellar, Dept. of Obstetrics and Gynecology, Unit II, Ruth Pfau KM Civil Hospital, Karachi. 74200. Pakistan., Fatima E; Erum Fatima, Dept. of Obstetrics and Gynecology, Unit II, Ruth Pfau KM Civil Hospital, Karachi. 74200. Pakistan., Imtiaz S; Sanam Imtiaz, Dept. of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan., Moosa PG; Palwasha Ghulam Moosa, Dept. of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan., Abbas K; Khawar Abbas, Dept. of Lab Sciences, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan., Jafri SB; Salma Batool Jafri, Dept. of Lab Sciences, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan., Khan S; Sadia Khan, Dept. of Lab Sciences, Sindh Institute of Urology and Transplantation (SIUT), Karachi. 74200. Pakistan.
Jazyk:	angličtina
Zdroj:	Pakistan journal of medical sciences [Pak J Med Sci] 2023 Jan-Feb; Vol. 39 (1), pp. 34-40.
DOI:	10.12669/pjms.39.1.6930
Abstrakt:	Objective: Several biomarkers like NGAL, KIM-1, IL-18, and Cystatin C has been previously reported as reliable marker to predict AKI. However, their predictive accuracy varies widely. We aim to observe the efficacy of multiple markers, NGAL, KIM-1, Cystatin C and IL-18, in obstetric population who are at risk of developing AKI. Methods: This prospective study was carried out between June 2021 to March 2022 at Department of Obstetrics & Gynecology Unit II, Ruth Pfau KM Civil Hospital and Sindh Institute of Urology & Transplant (SIUT), Karachi Pakistan. On women brought to OBGYN-ER with the diagnosis of hemorrhage (antepartum and postpartum), hypertension (pre-eclampsia and eclampsia) and sepsis. The urine samples and 3cc blood was collected at the time of admission, blood sample processed for biochemistry at time of admission and repeat blood samples for serum creatinine at 24 and 48 hours. Urine was stored at -80ºC and later evaluated for NGAL, KIM-1, Cystatin C and IL-18. Serum Cystatin C was also processed for the time zero sample. The biomarkers were tested using ELISA assays. Results: A total of 149 women were included in the study, 83% of these women were non-booked. Twenty-six (17%) women developed AKI. Serum Cystatin C, urinary Cystatin C and urinary NGAL were found significantly raised in women who developed AKI. While KIM-1 and IL-18 were not raised to statistical significance in this population. However, urinary KIM-1 along with urinary Cystatin C were significantly raised in women with positive quick sequential organ failure assessment (qSOFA). Conclusion: This study validates the use of serum and urinary Cystatin C and urinary NGAL as highly predictable biomarkers for the development of AKI and nullifies urinary IL-18 and KIM-1 in this regard. Competing Interests: Conflict of Interest: None. (Copyright: © Pakistan Journal of Medical Sciences.)
Databáze:	MEDLINE
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