Static Balance in Hereditary Spastic Paraplegias: a Cross-sectional Study.

Autor: Cubillos-Arcila DM; Neurogenetics: Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Graduate Program in Medicine: Medical Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.; Exercise Research Laboratory, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Martins VF; Graduate Program in Human Movement Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Zanardi APJ; Graduate Program in Human Movement Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Machado GD; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, Zip-code 90035-903, Brazil., Burguêz D; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, Zip-code 90035-903, Brazil., Gomeñuka NA; Exercise Research Laboratory, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.; Research Center, Universidad Católica de Las Misiones, UCAMI, Posadas, Argentina., Peyré-Tartaruga LA; Exercise Research Laboratory, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.; Graduate Program in Human Movement Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil., Saute JAM; Neurogenetics: Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. jsaute@hcpa.edu.br.; Graduate Program in Medicine: Medical Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. jsaute@hcpa.edu.br.; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, Zip-code 90035-903, Brazil. jsaute@hcpa.edu.br.; Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. jsaute@hcpa.edu.br.; Internal Medicine Department, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil. jsaute@hcpa.edu.br.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2024 Feb; Vol. 23 (1), pp. 162-171. Date of Electronic Publication: 2023 Jan 24.
DOI: 10.1007/s12311-023-01518-4
Abstrakt: Motor and somatosensory pathway dysfunction due to degeneration of long tracts in hereditary spastic paraplegias (HSP) indicates that postural abnormalities may be a relevant disease feature. However, balance assessments have been underutilized to study these conditions. How does the static balance of individuals with HSP with eyes open and closed differ from healthy controls, and how does it relate to disease severity? This cross-sectional case-control study assessed the static balance of 17 subjects with genetically confirmed HSP and 17 healthy individuals, evaluating the center of pressure (COP) variables captured by a force platform. The root-mean-square of velocities and mean of displacements amplitudes in mediolateral and anteroposterior axes were correlated with disease severity. All COP parameters' performances were significantly impaired in HSP subjects compared to controls (p < 0.001 for all comparisons). COP with eyes open and closed differed for all variables within the HSP group, whereas in the control group, differences were observed only for anteroposterior velocity and amplitude. Spastic Paraplegia Rating Scale presented moderate direct correlations with the most COP variables (Rho =  - 0.520 to - 0.736). HSP individuals presented significant postural instability with eyes open and to a greater extent with eyes closed, corroborating the clinical findings of somatosensorial and proprioceptive pathways dysfunction. The degrees of proprioceptive and motor impairments are mutually correlated, suggesting that similar pathophysiological mechanisms operate for the degeneration of these long tracts. COP parameters can be seen as disease severity biomarkers of HSP, and they should be assessed in future clinical trials.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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