Brain positron emission tomography (PET) and cognitive abnormalities one year after COVID-19.

Autor: Ferrucci R; Department of Health Science, Aldo Ravelli Research Center, University of Milan, Milan, Italy.; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Cuffaro L; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Capozza A; Nuclear Medicine Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Rosci C; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Maiorana N; Department of Health Science, Aldo Ravelli Research Center, University of Milan, Milan, Italy., Groppo E; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Reitano MR; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Poletti B; Department of Neurology and Laboratory of Neuroscience, IRCCS Auxologico Institute, Milan, Italy., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Auxologico Institute, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Tagliabue L; Nuclear Medicine Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Auxologico Institute, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Priori A; Department of Health Science, Aldo Ravelli Research Center, University of Milan, Milan, Italy. alberto.priori@unimi.it.; Neurology Unit, ASST-Santi Paolo e Carlo Hospital, Milan, Italy. alberto.priori@unimi.it.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2023 Apr; Vol. 270 (4), pp. 1823-1834. Date of Electronic Publication: 2023 Jan 24.
DOI: 10.1007/s00415-022-11543-8
Abstrakt: Emerging evidence indicates that the etiologic agent responsible for coronavirus disease 2019 (COVID-19), can cause neurological complications. COVID-19 may induce cognitive impairment through multiple mechanisms. The aim of the present study was to describe the possible neuropsychological and metabolic neuroimaging consequences of COVID-19 12 months after patients' hospital discharge. We retrospectively recruited 7 patients (age [mean ± SD] = 56 years ± 12.39, 4 men) who had been hospitalized for COVID-19 with persistent neuropsychological deficits 12 months after hospital discharge. All patients underwent cognitive assessment and brain ( 18 F-FDG) PET/CT, and one also underwent 18 F-amyloid PET/CT. Of the seven patients studied, four had normal glucose metabolism in the brain. Three patients showed various brain hypometabolism patterns: (1) unilateral left temporal mesial area hypometabolism; (2) pontine involvement; and (3) bilateral prefrontal area abnormalities with asymmetric parietal impairment. The patient who showed the most widespread glucose hypometabolism in the brain underwent an 18 F-amyloid PET/CT to assess the presence of Aβ plaques. This examination showed significant Aβ deposition in the superior and middle frontal cortex, and in the posterior cingulate cortex extending mildly in the rostral and caudal anterior cingulate areas. Although some other reports have already suggested that brain hypometabolism may be associated with cognitive impairment at shorter intervals from SarsCov-2 infection, our study is the first to assess cognitive functions, brain metabolic activity and in a patient also amyloid PET one year after COVID-19, demonstrating that cerebral effects of COVID-19 can largely outlast the acute phase of the disease and even be followed by amyloid deposition.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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