Selective integration of diverse taste inputs within a single taste modality.

Autor:	Deere JU; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Sarkissian AA; Neuroscience Graduate Program, Emory University, Atlanta, United States., Yang M; Department of Biology, Emory University, Atlanta, United States., Uttley HA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Martinez Santana N; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Nguyen L; Department of Biology, Emory University, Atlanta, United States., Ravi K; Department of Biology, Emory University, Atlanta, United States., Devineni AV; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States.; Neuroscience Graduate Program, Emory University, Atlanta, United States.; Department of Biology, Emory University, Atlanta, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Jan 24; Vol. 12. Date of Electronic Publication: 2023 Jan 24.
DOI:	10.7554/eLife.84856
Abstrakt:	A fundamental question in sensory processing is how different channels of sensory input are processed to regulate behavior. Different input channels may converge onto common downstream pathways to drive the same behaviors, or they may activate separate pathways to regulate distinct behaviors. We investigated this question in the Drosophila bitter taste system, which contains diverse bitter-sensing cells residing in different taste organs. First, we optogenetically activated subsets of bitter neurons within each organ. These subsets elicited broad and highly overlapping behavioral effects, suggesting that they converge onto common downstream pathways, but we also observed behavioral differences that argue for biased convergence. Consistent with these results, transsynaptic tracing revealed that bitter neurons in different organs connect to overlapping downstream pathways with biased connectivity. We investigated taste processing in one type of downstream bitter neuron that projects to the higher brain. These neurons integrate input from multiple organs and regulate specific taste-related behaviors. We then traced downstream circuits, providing the first glimpse into taste processing in the higher brain. Together, these results reveal that different bitter inputs are selectively integrated early in the circuit, enabling the pooling of information, while the circuit then diverges into multiple pathways that may have different roles. Competing Interests: JD, AS, MY, HU, NM, LN, KR, AD No competing interests declared (© 2023, Deere et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu