Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.

Autor: Boiarska Z; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Pérez-Peña H; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Abel AC; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Marzullo P; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Álvarez-Bernad B; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Bonato F; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Santini B; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Horvath D; Laboratory of Chemoinformatics, Faculty of Chemistry, University of Strasbourg, rue B. Pascal, 67081, Strasbourg, France., Lucena-Agell D; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Vasile F; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Sironi M; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Díaz JF; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Prota AE; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Pieraccini S; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Passarella D; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jan 24; Vol. 29 (5), pp. e202300069.
DOI: 10.1002/chem.202300069
Abstrakt: Invited for the cover of this issue are the groups of Professors Passarella and Pieraccini at the University of Milan, in collaboration with some of the members of TubInTrain consortium. The image depicts work with the elements of nature, in particular the destabilising effect of maytansinol (the constellation) on microtubules (the trees). Read the full text of the article at 10.1002/chem.202203431.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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