Compound K: A systematic review of its anticancer properties and probable mechanisms.

Autor: Tam DNH; Asia Shine Trading & Service Co., Ltd., Ho Chi Minh City, 700000, Vietnam.; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan., Nam NH; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Cuong NTK; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Oncology Department, Thu Duc City Hospital, Ho Chi Minh City, 700000, Vietnam., Hung DT; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Faculty of Medicine, University of Medicine and Pharmacy Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam., Soa DT; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Faculty of Pharmacy, Vinh Medical University, Nghe An, 43000-44000, Vietnam., Altom A; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Department of Internal Medicine, Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic., Tran L; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, 700000, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang City, 550000, Vietnam., Elhadad H; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Department of Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt., Huy NT; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; School of Tropical Medicine and Global Health (TMGH), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Jazyk: angličtina
Zdroj: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Aug; Vol. 37 (4), pp. 684-712. Date of Electronic Publication: 2023 Jan 31.
DOI: 10.1111/fcp.12874
Abstrakt: Panax ginseng is a common natural product, which is well-known to have a wide range of pharmacological activities in cancer. Its metabolite, compound K (CK), has been reported to have anticancer activity. We aimed to systematically review the literature for evidence of anticancer effects of CK. We conducted a systematic search in eight databases. We included all in vitro and in vivo studies investigating the anticancer effects of CK with no restrictions. Quality assessment was applied by ToxRTool. Fifty-four articles were included in our study. The purity of CK in our included studies was at least 95%. The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11). The in vivo studies reported a significant decrease in tumor volume in mice treated with CK. CK is a potential supplementary treatment in cancer chemotherapies. The safety and further clinical trials of CK should be explored for future drug development.
(© 2023 Société Française de Pharmacologie et de Thérapeutique.)
Databáze: MEDLINE
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