Effect of BaltPLA 2 , a phospholipase A 2 from Bothrops alternatus snake venom, on the viability of cells infected with dengue virus.

Autor: Dias EHV; Biotechnology Institute, Federal University of Catalão (UFCAT), Catalão, Goiás, Brazil. Electronic address: edigar.henrique@ufcat.edu.br., de Sousa Simamoto BB; Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., da Cunha Pereira DF; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Ribeiro MSM; Institute of Genetics and Biochemistry, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Santiago FM; Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: fmsantiago@ufu.br., de Oliveira F; Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: fabio@ufu.br., Yokosawa J; Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Mamede CCN; Institute of Biomedical Sciences, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: carlamamede@ufu.br.
Jazyk: angličtina
Zdroj: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2023 Apr; Vol. 88, pp. 105562. Date of Electronic Publication: 2023 Jan 20.
DOI: 10.1016/j.tiv.2023.105562
Abstrakt: Dengue fever is considered a major public health problem in tropical and subtropical regions. Our study analyzed the effect of BaltPLA 2, a phospholipase A 2 from Bothrops alternatus snake venom, on the viability of cells infected with Dengue virus. In presence of BaltPLA 2 , the viability of infected cells increased significantly in virucidal, post-treatment, and adsorption assays. Although preliminary these results reveal the need for further studies to investigated whether BaltPLA 2 has antiviral activity against Dengue virus.
Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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