Ecology and evolution of phages encoding anti-CRISPR proteins.

Autor: Pons BJ; ESI, Biosciences, University of Exeter, Cornwall Campus, Penryn, UK. Electronic address: b.pons@exeter.ac.uk., van Houte S; ESI, Biosciences, University of Exeter, Cornwall Campus, Penryn, UK., Westra ER; ESI, Biosciences, University of Exeter, Cornwall Campus, Penryn, UK., Chevallereau A; Université Paris Cité, Inserm U1016, CNRS UMR8104, Institut Cochin, F-75014 Paris, France. Electronic address: anne.chevallereau@inserm.fr.
Jazyk: angličtina
Zdroj: Journal of molecular biology [J Mol Biol] 2023 Apr 01; Vol. 435 (7), pp. 167974. Date of Electronic Publication: 2023 Jan 20.
DOI: 10.1016/j.jmb.2023.167974
Abstrakt: CRISPR-Cas are prokaryotic defence systems that provide protection against invasion by mobile genetic elements (MGE), including bacteriophages. MGE can overcome CRISPR-Cas defences by encoding anti-CRISPR (Acr) proteins. These proteins are produced in the early stages of the infection and inhibit the CRISPR-Cas machinery to allow phage replication. While research on Acr has mainly focused on their discovery, structure and mode of action, and their applications in biotechnology, the impact of Acr on the ecology of MGE as well as on the coevolution with their bacterial hosts only begins to be unravelled. In this review, we summarise our current understanding on the distribution of anti-CRISPR genes in MGE, the ecology of phages encoding Acr, and their coevolution with bacterial defence mechanisms. We highlight the need to use more diverse and complex experimental models to better understand the impact of anti-CRISPR in MGE-host interactions.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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