[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].

Autor:	Arutyunov AG; Association «Eurasian Association of Therapists»; National Institute of Health named after S. Avdalbekyan., Tarlovskaya EI; Association «Eurasian Association of Therapists»; Privolzhsky Research Medical University., Galstyan GR; Scientific Medical Research Center of Endocrinology of the Ministry of Health of Russia., Batluk TI; Association «Eurasian Association of Therapists»; Pirogov Russian National Research Medical University., Bashkinov RA; Association «Eurasian Association of Therapists»; North-Western State Medical University named after I.I. Mechnikov., Arutyunov GG; Association «Eurasian Association of Therapists»; Pirogov Russian National Research Medical University., Belenkov YN; Sechenov University., Konradi AO; Almazov National Medical Research Centre' of the Ministry of Health of the Russian Federation., Lopatin YM; Volgograd State Medical University., Rebrov AP; Saratov State Medical University named after V.I. Razumovsky., Tereshchenko SN; National medical research center of cardiology., Chesnikova AI; Rostov State Medical University., Hayrapetyan HG; Erebouni Cardiology Center., Babin AP; Nicolae Testemitanu State University of Medicine and Pharmacy., Bakulin IG; North-Western State Medical University named after I.I. Mechnikov., Bakulina NV; North-Western State Medical University named after I.I. Mechnikov., Balykova LA; Ogarev Mordovia State University., Blagonravova AS; Privolzhsky Research Medical University., Boldina MV; Privolzhsky Research Medical University., Butomo MI; Pavlov First State Medical University of St. Petersburg., Vaisberg AR; Privolzhsky Research Medical University., Galyavich AS; The Republican Center for Cardiovascular Diseases of State Autonomous Institution of Health «Interregional Clinical Diagnostic Center»; Kazan State Medical University., Gomonova VV; North-Western State Medical University named after I.I. Mechnikov., Grigoryeva NY; National Research Lobachevsky State University of Nizhni Novgorod., Gubareva IV; Samara State Medical University, Internal Diseases Department., Demko IV; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital»., Evzerikhina AV; Krasnogorsk city hospital №1., Zharkov AV; Kirovsk Interdistrict Hospital., Zateishchikova AA; City Hospital №51., Kamilova UK; The Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Kim ZF; Medical Center «GAUZ GKB №7»., Kuznetsova TY; Petrozavodsk State University., Kulikov AN; Pavlov First State Medical University of St. Petersburg., Lareva NAV; Chita State Medical Academy., Makarova EV; Privolzhsky Research Medical University., Malchikova SV; Kirov State Medical University., Nedogoda SV; Volgograd State Medical University., Petrova MM; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Pochinka IG; Privolzhsky Research Medical University; Privolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod., Protasov KV; Irkutsk State Medical Academy of Postgraduate Education., Protsenko DN; Pirogov Russian National Research Medical University; Moscow City Clinical Hospital №40., Ruzanov DY; Educational Institution «Gomel State Medical University»., Saiganov SA; North-Western State Medical University named after I.I. Mechnikov., Sarybaev AS; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Selezneva NM; Ogarev Mordovia State University., Sugraliev AB; Asfendiyarov Kazakh National Medical University., Fomin IV; Privolzhsky Research Medical University., Khlynova OV; Perm State Medical University named after E.A. Vagner., Chizhova OY; North-Western State Medical University named after I.I. Mechnikov., Shaposhnik II; South-Ural State Medical University., Schukarev DA; Kirovsk Interdistrict Hospital., Abdrakhmanova AK; Kazakh University of Continuing Education; Clinical Infectious Diseases Hospital named after I. Zhekenovа., Avetisyan SA; Yerevan State Medical University., Avoyan HG; Erebouni Cardiology Center., Azaryan KK; Erebouni Cardiology Center., Aimakhanova GT; Asfendiyarov Kazakh National Medical University., Ayypova DA; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Akunov AC; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Alieva MK; North-Western State Medical University named after I.I. Mechnikov., Almukhambedova AR; Central Clinical Hospital of the Office of the President of RF., Aparkina AV; Saratov State Medical University named after V.I. Razumovsky., Aruslanova OR; Perm Regional Clinical Cardiological Dispensary., Ashina EY; Privolzhsky Research Medical University., Badina ONY; The Volga District Medical Centre, Federal Medical and Biological Agency of Russia., Barysheva OY; Petrozavodsk State University., Batchaeva AS; Pirogov Russian National Research Medical University., Bitieva AM; North-Western State Medical University named after I.I. Mechnikov., Bikhteev IU; North-Western State Medical University named after I.I. Mechnikov., Borodulina NA; Perm Regional Clinical Cardiological Dispensary., Bragin MV; North-Western State Medical University named after I.I. Mechnikov., Brazhnik VA; City Hospital №51., Budu AM; Clinical City Hospital №1., Bykova GA; Perm State Medical University named after E.A. Vagner., Vagapova KR; FSBI 'Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation., Varlamova DD; Petrozavodsk State University., Vezikova NN; Petrozavodsk State University., Verbitskaya EA; Regional state budgetary healthcare institution «Regional Clinical Hospital»., Vilkova OE; National Research Lobachevsky State University of Nizhni Novgorod., Vinnikova EA; North-Western State Medical University named after I.I. Mechnikov., Vustina VV; Perm Regional Clinical Hospital., Galova EA; Privolzhsky Research Medical University., Genkel VV; South-Ural State Medical University., Giller DB; Sechenov University., Gorshenina EI; Ogarev Mordovia State University., Grigoryeva EV; Saratov State Medical University named after V.I. Razumovsky., Gubareva EY; Samara State Medical University, Internal Diseases Department., Dabylova GM; Asfendiyarov Kazakh National Medical University., Demchenko AI; Samara State Medical University, Internal Diseases Department., Dolgikh OY; State Budgetary Institution of Healthcare of the Samara Region «Chapaevskaya Central City Hospital», Chapaevsk., Duishobaev MY; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Evdokimov DS; North-Western State Medical University named after I.I. Mechnikov., Egorova KE; Republic hospital n.a. V.A. Baranov., Ermilova AN; Association «Eurasian Association of Therapists»; «Empathy» (mental health centre)., Zheldybaeva AE; Asfendiyarov Kazakh National Medical University., Zarechnova NV; The Volga District Medical Centre, Federal Medical and Biological Agency of Russia., Zimina YD; City Clinical Hospital №25., Ivanova SY; State Budgetary Medical Institution Republic of Karelia Hospital for Veterans., Ivanchenko EY; Privolzhsky Research Medical University., Ilina MV; Kirovsk Interdistrict Hospital., Kazakovtseva MV; Kirov State Medical University., Kazymova EV; Private Healthcare Institution «Clinical Hospital RZHD Meditsyna at Samara railway station»., Kalinina YS; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Kamardina NA; The Volga District Medical Centre, Federal Medical and Biological Agency of Russia., Karachenova AM; Chita State Medical Academy., Karetnikov IA; Irkutsk regional clinical hospital of Conferred Order of Merit., Karoli NA; Saratov State Medical University named after V.I. Razumovsky., Karsiev MK; North-Western State Medical University named after I.I. Mechnikov., Kaskaeva DS; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Kasymova KF; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Kerimbekova ZB; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Kim ES; Medical Center «GAUZ GKB №7»., Kiseleva NV; Nizhniy Novgorod City Hospital №40., Klimenko DA; Samara State Medical University, Internal Diseases Department., Klimova AV; Pirogov Russian National Research Medical University; Moscow City State Outpatient Hospital №13440., Kovalishena OV; Privolzhsky Research Medical University., Kozlov SV; City Hospital №51., Kolmakova EV; North-Western State Medical University named after I.I. Mechnikov., Kolchinskaya TP; Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour «City Clinical Hospital №1»., Kolyadich MI; South-Ural State Medical University; Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour «City Clinical Hospital №1»., Kondryakova OV; Samara State Medical University, Internal Diseases Department., Konoval MP; North-Western State Medical University named after I.I. Mechnikov., Konstantinov DY; Samara State Medical University, Internal Diseases Department., Konstantinova EA; Samara State Medical University, Internal Diseases Department., Kordyukova VA; Privolzhsky Research Medical University., Koroleva EV; National Research Lobachevsky State University of Nizhni Novgorod; City clinical hospital №5 of Nizhniy Novgorod, National Research Lobachevsky State University of Nizhni Novgorod., Kraposhina AY; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital»., Kryukova TV; Association «Eurasian Association of Therapists»., Kuznetsova AS; South-Ural State Medical University., Kuzmina TY; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Kuzmichev KV; Privolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod., Kulchoroeva CK; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Kuprina TV; Petrozavodsk State University., Kuranova IAM; Gorodetskaya Central City Hospital of Nizhniy Novgorod Region., Kurenkova LVV; Republic hospital n.a. S.V. Katkov., Kurchugina NY; Samara State Medical University, Internal Diseases Department., Kushubakova NA; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Levankova VI; Petrozavodsk City polyclinic №1., Ledyaeva AA; Volgograd State Medical University., Lisun TV; Moscow City Clinical Hospital №40., Lisyanskaya VE; Pavlov First State Medical University of St. Petersburg., Lyubavina NA; Privolzhsky Research Medical University., Magdeeva NA; Saratov State Medical University named after V.I. Razumovsky., Mazalov KV; The Volga District Medical Centre, Federal Medical and Biological Agency of Russia., Mayseenko VI; Educational Institution «Gomel State Medical University»., Makarova AS; Irkutsk State Medical Academy of Postgraduate Education., Maripov AM; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Markov NV; Pavlov First State Medical University of St. Petersburg., Marusina AA; Kirovsk Interdistrict Hospital., Melnikov ES; Association «Eurasian Association of Therapists»; North-Western State Medical University named after I.I. Mechnikov., Metlinskaya AI; Pavlov First State Medical University of St. Petersburg., Moiseenko NB; National Research Lobachevsky State University of Nizhni Novgorod., Muradova FN; Privolzhsky Research Medical University., Muradyan RG; Global Medical System clinics and hospitals., Musaelyan SN; Yerevan State Medical University., Nekaeva ES; Privolzhsky Research Medical University., Nikitina NM; Saratov State Medical University named after V.I. Razumovsky., Nifontov SE; Pavlov First State Medical University of St. Petersburg., Obolentseva EY; Pavlov First State Medical University of St. Petersburg., Obukhova AA; Pavlov First State Medical University of St. Petersburg., Ogurlieva BB; Pirogov Russian National Research Medical University; Moscow City Clinical Hospital №4., Odegova AA; Kirov State Medical University., Omarova YV; Privolzhsky Research Medical University., Omurzakova NA; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Ospanova SO; Asfendiyarov Kazakh National Medical University., Pavlova VA; Pavlov First State Medical University of St. Petersburg., Pakhomova EVP; GBUZ RK «Republican tuberculosis dispensary»., Petrov LD; Health Center of Briceni., Plastinina SS; Privolzhsky Research Medical University., Platonov DA; City Hospital №51., Pogrebetskaya VAA; SBHI of Nizhniy Novgorod Region «City Clinical Hospital №38»., Polyakov DV; Pirogov Russian National Research Medical University., Polyakov DS; Privolzhsky Research Medical University., Ponomarenko EEV; Medical center «Zimamed»., Popova LL; Samara State Medical University, Internal Diseases Department., Potanin AA; Pavlov First State Medical University of St. Petersburg., Prokofieva NA; North-Western State Medical University named after I.I. Mechnikov., Rabik YD; Pavlov First State Medical University of St. Petersburg., Rakov NA; Privolzhsky Research Medical University., Rakhimov AN; The Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Rozanova NA; Krasnogorsk city hospital №1., Samus IV; Kemerovo regional clinical psychiatric hospital., Serikbolkyzy S; Asfendiyarov Kazakh National Medical University., Sidorkina YA; City Hospital №51., Simonov AA; North-Western State Medical University named after I.I. Mechnikov., Skachkova VV; Perm Regional Clinical Hospital., Skvortsova RD; Pavlov First State Medical University of St. Petersburg., Skuridin DS; Pavlov First State Medical University of St. Petersburg., Solovieva DV; National Research Lobachevsky State University of Nizhni Novgorod., Solovieva IA; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital»., Sukhomlinova IM; Saint-Petersburg hospital for veterans., Sushilova AG; North-Western State Medical University named after I.I. Mechnikov., Tagaeva DR; The Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation., Titoykina YV; Ogarev Mordovia State University., Tikhonova EP; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Tokmin DS; Labs of the Future., Tolmacheva AA; Novosibirsk State Medical University; SBHCI of Novosibirsk region «Clinical Polyclinic №3»., Torgunakova MS; Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky., Trenogina KV; Perm Regional Clinical Hospital., Trostyanetskaya NAA; North-Western State Medical University named after I.I. Mechnikov., Trofimov DA; Kazan State Medical University; Medical Center «GAUZ GKB №7»., Trubnikova MA; Association «Eurasian Association of Therapists»; LLC 'Fresenius Medical Care Kuban'., Tulichev AA; Privolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Clinical Hospital №3., Tursunova AT; Asfendiyarov Kazakh National Medical University., Ulanova ND; Privolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod., Fatenkov OV; Samara State Medical University, Internal Diseases Department., Fedorishina OV; Irkutsk State Medical Academy of Postgraduate Education., Fil TS; North-Western State Medical University named after I.I. Mechnikov., Fomina IY; Privolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Outpatient Hospital №1., Fominova IS; Republic of Mordovia Clinical Hospital №4., Frolova IA; The Volga District Medical Centre, Federal Medical and Biological Agency of Russia., Tsvinger SM; Chita State Medical Academy., Tsoma VV; Volgograd State Medical University., Cholponbaeva MB; National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov., Chudinovskikh TSI; Kirov State Medical University., Shavrin IV; Medsi., Shevchenko OA; SBHI of Samara Region «Samara City Polyclinic №3»., Shikhaliev DR; Pavlov First State Medical University of St. Petersburg., Shishkina EA; Perm State Medical University named after E.A. Vagner., Shishkov KY; Samara State Medical University, Internal Diseases Department., Shcherbakov SY; Kazan State Medical Academy., Shcherbakova GV; Sechenov University., Yausheva EA; Private Healthcare Institution «Clinical Hospital RZHD Meditsyna at Samara railway station».
Jazyk:	ruština
Zdroj:	Problemy endokrinologii [Probl Endokrinol (Mosk)] 2023 Jan 24; Vol. 68 (6), pp. 89-109. Date of Electronic Publication: 2023 Jan 24.
DOI:	10.14341/probl13165
Abstrakt:	Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI). Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period. Materials and Methods: AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected  the  data  of  hospitalized  patients  and  included  3  visits.  All  subjects  were  divided  into  3  groups:  not  overweight  (n=2139), overweight (n=2931) and obese (n=2666). Results: A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The  patients  with  the  1st  and  2nd  degree  obesity,  undergoing  the  inpatient  treatment,  tended  to  have  a  higher  probability  of  a  mortality  rate.  While  in  case  of  morbid  obesity  patients  this  tendency  is  the  most  significant  (odds  ratio  -  1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION.  Overweight  and/or  obesity  is  a  significant  risk  factor  for severe  course  of  the  new  coronavirus  infection  and  the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
Databáze:	MEDLINE
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