Abnormal Conduction Zone Detected by Isochronal Late Activation Mapping Accurately Identifies the Potential Atrial Substrate and Predicts the Atrial Fibrillation Ablation Outcome After Pulmonary Vein Isolation.

Autor:	Kuo MJ; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.).; Cardiovascular Center, Taichung Veterans General Hospital (M.-J.K., S.-A.C.)., Ton AN; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Tam Duc Heart hospital, Vietnam (A.N.-K.T.)., Lo LW; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Lin YJ; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chang SL; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Hu YF; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chung FP; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Tuan TC; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chao TF; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Liao JN; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chang TY; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Lin CY; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Kuo L; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Wu CI; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Liu CM; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Cheng WH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Liu SH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chhay C; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Kao PH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chen WT; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Hsu CY; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.)., Chen SA; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital (M.-J.K., A.N.-K.T., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., C.C., P.-H.K., W.-T.C., C.-Y.H., S.-A.C.).; Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang-Ming Chiao-Tung University, Taipei (M.-J.K., L.-W.L., Y.-J.L., S.-L.C., Y.-F.H., F.-P.C., T.-C.T., T.-F.C., J.-N.L., T.-Y.C., C.-Y.L., L.K., C.-I.W., C.-M.L., W.-H.C., S.-H.L., S.-A.C.).; Cardiovascular Center, Taichung Veterans General Hospital (M.-J.K., S.-A.C.).; National Chung Hsing University, Taichung, Taiwan (S.-A.C.).
Jazyk:	angličtina
Zdroj:	Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2023 Feb; Vol. 16 (2), pp. e011149. Date of Electronic Publication: 2023 Jan 23.
DOI:	10.1161/CIRCEP.122.011149
Abstrakt:	Background: The presence of abnormal substrate of left atrium is a predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation. We aimed to investigate the isochronal late activation mapping to access the abnormal conduction velocity for predicting AF ablation outcome. Methods: Forty-five paroxysmal AF patients (30 males, 57.8±8.7 years old) who underwent pulmonary vein isolation were enrolled. Isochronal late activation mapping was retrospectively constructed with 2 different windows of interest: from onset of P wave to onset of QRS wave on surface electrocardiography (W1) and 74 ms tracking back from the end of P wave (W2). Deceleration zone was defined as regions with 3 isochrones (DZa) or ≥4 isochrones (DZb) within a 1 cm radius on the isochronal late activation mapping, and the estimated conduction velocity (ECV) are 0.27 m/s and <0.20 m/s for DZa and DZb, respectively in W2. The distribution of deceleration zone was compared with the location of low-voltage zone (bipolar voltage ≤0.5 mV). Any recurrence of atrial arrhythmias was defined as the primary end point during follow ups after a 3-month blanking period. Results: Pulmonary vein isolation was performed in all patients, and there were 2 patients (4.4%) received additional extrapulmonary vein ablation. After a mean follow-up of 12.7±4.5 months, recurrence of AF occurred in 14 patients (31.1%). Patients with the presence of DZb in W2 had higher AF recurrence (Kaplan-Meier event rate estimates: HR, 9.41 [95% CI, 2.61-33.90]; log-rank P <0.0001). There were 52.6% of the DZb locations in W2 comparable to the distributions of low-voltage zone and 47.4% DZb were distributed in the area without low-voltage zone. Conclusions: Deceleration zone detected by isochronal late activation mapping represents a critical AF substrate, it accurately predicts the AF recurrence following ablation in patients with paroxysmal AF.
Databáze:	MEDLINE
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