Sickle cells are not necessarily protective against falciparum- A case report.

Autor: Rasalam JE; Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India., Kumar S; Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India., Sujith K; Department of Clinical Haematology, Christian Medical College, Vellore, Tamil Nadu, India., Fouzia NA; Department of Clinical Haematology, Christian Medical College, Vellore, Tamil Nadu, India., Palle A; Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India., Daniel D; Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India., Nair SC; Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Asian journal of transfusion science [Asian J Transfus Sci] 2022 Jul-Dec; Vol. 16 (2), pp. 266-268. Date of Electronic Publication: 2022 May 26.
DOI: 10.4103/ajts.ajts_122_21
Abstrakt: The relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis and parasite death. Although patients with sickle cell trait are relatively protected, malaria can often lead to marked anemia in them due to hemolysis. We report an unusual case of a child with homozygous SCD presenting with falciparum malaria and had hyper parasitemia and severe anemia which completely resolved following treatment. Clinical suspicion in our case arose considering the endemic nature of malaria in our country. The two overlapping injuries to spleen reduced the clearance of parasites by the spleen as evidenced by high parasite load. Our case report reinforces malaria as a cause of clinical worsening of SCD and highlights the importance of a multifactorial approach in the management of worsening anemia in SCD.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Asian Journal of Transfusion Science.)
Databáze: MEDLINE
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