An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera .

Autor:	Azlan UK; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia., Khairul Annuar NA; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia., Mediani A; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia., Aizat WM; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia., Damanhuri HA; Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia., Tong X; School of Life Sciences, Anhui University of Chinese Medicine, Hefei, China., Yanagisawa D; Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan., Tooyama I; Medical Innovation Research Center, Shiga University of Medical Science, Otsu, Japan., Wan Ngah WZ; Medical Innovation Research Center, Shiga University of Medical Science, Otsu, Japan., Jantan I; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia., Hamezah HS; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2023 Jan 05; Vol. 13, pp. 1035220. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.1035220
Abstrakt:	Neurodegenerative diseases (NDs) are sporadic maladies that affect patients' lives with progressive neurological disabilities and reduced quality of life. Neuroinflammation and oxidative reaction are among the pivotal factors for neurodegenerative conditions, contributing to the progression of NDs, such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS) and Huntington's disease (HD). Management of NDs is still less than optimum due to its wide range of causative factors and influences, such as lifestyle, genetic variants, and environmental aspects. The neuroprotective and anti-neuroinflammatory activities of Moringa oleifera have been documented in numerous studies due to its richness of phytochemicals with antioxidant and anti-inflammatory properties. This review highlights up-to-date research findings on the anti-neuroinflammatory and neuroprotective effects of M. oleifera , including mechanisms against NDs. The information was gathered from databases, which include Scopus, Science Direct, Ovid-MEDLINE, Springer, and Elsevier. Neuroprotective effects of M. oleifera were mainly assessed by using the crude extracts in vitro and in vivo experiments. Isolated compounds from M. oleifera such as moringin, astragalin, and isoquercitrin, and identified compounds of M. oleifera such as phenolic acids and flavonoids (chlorogenic acid, gallic acid, ferulic acid, caffeic acid, kaempferol, quercetin, myricetin, (-)-epicatechin, and isoquercitrin) have been reported to have neuropharmacological activities. Therefore, these compounds may potentially contribute to the neuroprotective and anti-neuroinflammatory effects. More in-depth studies using in vivo animal models of neurological-related disorders and extensive preclinical investigations, such as pharmacokinetics, toxicity, and bioavailability studies are necessary before clinical trials can be carried out to develop M. oleifera constituents into neuroprotective agents. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Azlan, Khairul Annuar, Mediani, Aizat, Damanhuri, Tong, Yanagisawa, Tooyama, Wan Ngah, Jantan and Hamezah.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu