A Salmonella enterica Serovar Oranienburg Clone Caused a Cluster of Bacteremia Cases in Persons With No Recognizable Underlying Diseases in Japan.

Autor: Ooka T; Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Gotoh Y; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Hatanaka S; Department of Emergency and General Internal Medicine, Imamura General Hospital, Kagoshima, Japan., Yoshimori M; Department of Infection Control and Prevention, Imamura General Hospital, Kagoshima, Japan., Nishitarumizu K; Department of Emergency and General Internal Medicine, Imamura General Hospital, Kagoshima, Japan., Kojo K; Department of Pediatrics, Kagoshima Children's Hospital, Kagoshima, Japan., Kosakamoto H; Department of Internal Medicine, Kokubu Seikyo Hospital, Kagoshima, Japan., Sameshima K; Department of Pediatrics, Kagoshima City Hospital, Kagoshima, Japan., Kuroki Y; Department of Internal Medicine, Koga General Hospital, Miyazaki, Japan., Chibana N; Department of General Internal Medicine, Naha City Hospital, Okinawa, Japan., Doi Y; Kagoshima City Public Health Center, Kagoshima, Japan., Yoshino S; Clinical Microbiology Section, Miyazaki Prefectural Institute for Public Health and Environment, Miyazaki, Japan., Harada T; Division of Microbiology, Osaka Institute of Public Health, Osaka, Japan., Seto K; Division of Microbiology, Osaka Institute of Public Health, Osaka, Japan., Ikeda T; Department of Infectious Diseases, Hokkaido Institute of Public Health, Hokkaido, Japan., Miyanohara H; Department of Clinical Laboratory, Kagoshima Prefectural Comprehensive Health Center, Kagoshima, Japan., Nakayama K; Microorganism Section, Kagoshima Prefectural Institute for Environmental Research and Public Health, Kagoshima, Japan., Gokuden M; Microorganism Section, Kagoshima Prefectural Institute for Environmental Research and Public Health, Kagoshima, Japan., Imuta N; Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Kawamura H; Department of Infection Control and Prevention, Kagoshima University Hospital, Kagoshima, Japan., Ogura Y; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.; Division of Microbiology, Department of Infectious Medicine, Kurume University, Fukuoka, Japan., Hayashi T; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Nishi J; Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2022 Dec 28; Vol. 10 (1), pp. ofac695. Date of Electronic Publication: 2022 Dec 28 (Print Publication: 2023).
DOI: 10.1093/ofid/ofac695
Abstrakt: Background: Salmonella enterica subspecies enterica serovar Oranienburg (SO) is a foodborne pathogen but rarely causes systemic infections such as bacteremia. Between July and September 2018, bacteremia cases caused by SO were identified in 12 persons without any underlying medical conditions in the southern Kyushu area of Japan.
Methods: Randomly amplified polymorphic DNA (RAPD) analysis was performed to investigate the genetic similarity of the 12 bacteremia-related strains and other Japanese isolates. Furthermore, a series of whole-genome sequence (WGS)-based phylogenetic analyses was performed with a global SO strain set (n = 1648).
Results: The resolution power of RAPD was insufficient to investigate the genetic similarity between the bacteremia-related strains and other strains. WGS-based phylogenetic analyses revealed that the bacteremia-related strains formed a tight cluster along with 2 strains isolated from asymptomatic carriers in 2018 in the same area, with a maximum within-cluster single-nucleotide polymorphism (SNP) distance of 11. While several strains isolated in the United States and the United Kingdom were found to be closely related to the bacteremia-related strains, 2 strains isolated in 2016 in the southern Kyushu area were most closely related, with SNP distances of 4-11 and 5-10, and had the same plasmids as the bacteremia-related strains.
Conclusions: The 12 bacteremia cases identified were caused by a single SO clone. As none of the bacteremia patients had any underlying diseases, this clone may be prone to cause bacteremia. Although further analyses are required to understand its virulence, particular attention should be given to this clone and its close relatives in the surveillance of nontyphoidal salmonellae.
Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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