Mesoangioblasts at 20: From the embryonic aorta to the patient bed.

Autor:	Cossu G; Division of Cell Matrix Biology and Regenerative Medicine. University of Manchester, Manchester, United Kingdom.; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.; Muscle Research Unit, Charité Medical Faculty and Max Delbrück Center, Berlin, Germany., Tonlorenzi R; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Brunelli S; School of Medicine and Surgery, University of Milano Bicocca, Milan, Italy., Sampaolesi M; Translational Cardiomyology Laboratory, Stem Cell and Developmental Biology Unit, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Histology and Medical Embryology Unit, Department of Anatomy, Forensic Medicine and Orthopaedics, Sapienza University, Rome, Italy., Messina G; Department of Biosciences, University of Milan, Milan, Italy., Azzoni E; School of Medicine and Surgery, University of Milano Bicocca, Milan, Italy., Benedetti S; UCL Great Ormond Street Institute of Child Health and NIHR GOSH Biomedical Research Centre, London, United Kingdom., Biressi S; Department of Cellular, Computational and Integrative Biology (CIBIO) and Dulbecco Telethon Institute, University of Trento, Trento, Italy., Bonfanti C; Department of Biosciences, University of Milan, Milan, Italy., Bragg L; Division of Cell Matrix Biology and Regenerative Medicine. University of Manchester, Manchester, United Kingdom., Camps J; Bayer AG, Research and Development, Pharmaceuticals, Berlin, Germany., Cappellari O; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', Bari, Italy., Cassano M; Lunaphore Technologies SA, Tolochenaz, Switzerland., Ciceri F; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Coletta M; Histology and Medical Embryology Unit, Department of Anatomy, Forensic Medicine and Orthopaedics, Sapienza University, Rome, Italy., Covarello D; AGC Biologicals, Milan, Italy., Crippa S; San Raffaele-Telethon Institute of Gene Theray, IRCCS Ospedale San Raffaele, Milan, Italy., Cusella-De Angelis MG; Department of Anatomy, University of Pavia, Pavia, Italy., De Angelis L; Histology and Medical Embryology Unit, Department of Anatomy, Forensic Medicine and Orthopaedics, Sapienza University, Rome, Italy., Dellavalle A; Cord Blood Bank, InScientiaFides, San Marino., Diaz-Manera J; John Walton Muscular Dystrophy Research Centre, Newcastle University, United Kingdom., Galli D; Department of Medicine and Surgery, University of Parma, Parma, Italy., Galli F; Division of Cell Matrix Biology and Regenerative Medicine. University of Manchester, Manchester, United Kingdom., Gargioli C; Department of Biology, University of Tor Vergata, Rome, Italy., Gerli MFM; UCL Department of Surgical Biotechnology and Great Ormond Street Institute of Child Health, London, United Kingdom., Giacomazzi G; CellCarta, Gosselies, Belgium., Galvez BG; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Universidad Complutense de Madrid, Madrid, Spain., Hoshiya H; CellFiber Co., Ltd, Tokyo, Japan., Guttinger M; IFO, Istituti Fisioterapici Ospedalieri, Rome, Italy., Innocenzi A; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Minasi MG; Lavitaminasi, Clinical Nutrition and Reproductive Medicine, Rome, Italy., Perani L; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Previtali SC; Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Quattrocelli M; Division of Molecular Cardiovascular Biology, University of Cincinnati, Cincinnati, OH, United States., Ragazzi M; Gubra ApS, Horsholm, Denmark., Roostalu U; Roche Institute for Translational Bioengineering (ITB), pRED Basel, Basel, Switzerland., Rossi G; Institute of Translational Pharmacology, National Research Council, Rome, Italy., Scardigli R; Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, United States., Sirabella D; University College London, Great Ormond Street Hospital for Children and the Francis Crick Institute, London, United Kingdom., Tedesco FS; Laboratory of Neuroscience, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile., Torrente Y; UCL Great Ormond Street Institute of Child Health and NIHR GOSH Biomedical Research Centre, London, United Kingdom., Ugarte G; Laboratory of Neuroscience, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2023 Jan 04; Vol. 13, pp. 1056114. Date of Electronic Publication: 2023 Jan 04 (Print Publication: 2022).
DOI:	10.3389/fgene.2022.1056114
Abstrakt:	In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded in vitro (also from human muscle) and cross the vessel wall, suggested a protocol for the cell therapy of muscular dystrophies. We tested this protocol in mice and dogs before proceeding to the first clinical trial on Duchenne Muscular Dystrophy patients that showed safety but minimal efficacy. In the last years, we have worked to overcome the problem of low engraftment and tried to understand their role as auxiliary myogenic progenitors during development and regeneration. Competing Interests: MC is employed by Lunapore. GG and HH by Cell Fiber.Co. GR by Roche and UR by Gupra. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer (KV) declared a shared parent affiliation with the author(s) (MQ) to the handling editor at the time of review. (Copyright © 2023 Cossu, Tonlorenzi, Brunelli, Sampaolesi, Messina, Azzoni, Benedetti, Biressi, Bonfanti, Bragg, Camps, Cappellari, Cassano, Ciceri, Coletta, Covarello, Crippa, Cusella-De Angelis, De Angelis, Dellavalle, Diaz-Manera, Galli, Galli, Gargioli, Gerli, Giacomazzi, Galvez, Hoshiya, Guttinger, Innocenzi, Minasi, Perani, Previtali, Quattrocelli, Ragazzi, Roostalu, Rossi, Scardigli, Sirabella, Tedesco, Torrente and Ugarte.)
Databáze:	MEDLINE
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