Evaluation of the relationship between acute kidney injury and renin angiotensin system inhibition in COVID-19 patients.

Autor:	Yesil EE; Department of Nephrology, Umraniye Training and Research Hospital, Istanbul, Turkiye., Kayabasi H; Department of Nephrology, Umraniye Training and Research Hospital, Istanbul, Turkiye., Sit D; Department of Nephrology, Umraniye Training and Research Hospital, Istanbul, Turkiye., Demirbas MB; Department of Nephrology, Umraniye Training and Research Hospital, Istanbul, Turkiye., Pehlivan O; Department of Rheumatology, Umraniye Training and Research Hospital, Istanbul, Turkiye., Arslan A; Department of Internal Medicine, Umraniye Training and Research Hospital, Istanbul, Turkiye., Aydin T; Department of Internal Medicine, Umraniye Training and Research Hospital, Istanbul, Turkiye., Gokcin Z; Department of Internal Medicine, Umraniye Training and Research Hospital, Istanbul, Turkiye.
Jazyk:	angličtina
Zdroj:	Northern clinics of Istanbul [North Clin Istanb] 2022 Dec 22; Vol. 9 (6), pp. 541-549. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
DOI:	10.14744/nci.2022.87360
Abstrakt:	Objective: In patients with coronavirus disease 2019 (COVID-19), acute kidney injury (AKI) may alter the clinical course and outcome of the disease. In this study, the association of AKI with renin angiotensin system (RAS) inhibitor treatment and its clinical consequences were examined in COVID-19 patients admitted to our hospital during the initial stages of the pandemic. Methods: A total of 407 patients between 18 and 85 years of age (202 male and 205 female) admitted to the Umraniye Research And Training Hospital between May 2020 and August 2020 with a diagnosis of COVID-19 were included in the study. Patients were categorized as follows: Group 1, subjects with no chronic conditions (n=150); and Group 2, subjects with comorbid conditions (n=257). Group 2 was subdivided into Group 2A (receiving angiotensin receptor blocker [ARB])/(angiotensin converting enzyme inhibitor [ACEI], n=81), and Group 2B (not receiving ARB/ACEI, n=176). Results: Hypertension was the most frequent comorbid condition (36.4%). There was no difference in survival rates between the patients who used RAS inhibitor and the ones who did not based on log rank test (p=0.342). Fifty-four patients (13.4%) had developed AKI during the time frame of the disease. In patients with chronic diseases such as hypertension, the use of RAS inhibitory medication was not associated with developing AKI (OR 95% CI: 0.317-1.358; p=0.256). The survival rate of the patients with AKI was significantly lower than patients without AKI (p<0.0001). Conclusion: COVID-19 may cause renal injury represents a risk factor for mortality. Therefore, detection of renal injury has a particular prognostic importance. Competing Interests: No conflict of interest was declared by the authors. (© Copyright 2022 by Istanbul Provincial Directorate of Health.)
Databáze:	MEDLINE
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