IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study.

Autor:	Shojaei M; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.; Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia.; Department of Medicine, Sydney Medical School Nepean, Nepean Hospital, University of Sydney, Penrith, NSW, Australia., Shamshirian A; Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Monkman J; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Grice L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia., Tran M; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Tan CW; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Teo SM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Rodrigues Rossi G; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., McCulloch TR; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Nalos M; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia., Raei M; Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Razavi A; Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Ghasemian R; Antimicrobial Resistance Research Centre, Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran., Gheibi M; Student Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Science, Sari, Iran., Roozbeh F; Mazandaran University of Medical Sciences, Sari, Iran., Sly PD; Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia., Spann KM; Centre for Immunology and Infection Control, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Chew KY; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Zhu Y; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Xia Y; School of Science, Edith Cowan University; School of Biomedical Science, University of Western Australia, Perth, WA, Australia., Wells TJ; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Senegaglia AC; Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.; Core for Cell Technology, School of Medicine, PontifìciaUniversidade Católica do Paraná, Curitiba, Brazil., Kuniyoshi CL; Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.; Core for Cell Technology, School of Medicine, PontifìciaUniversidade Católica do Paraná, Curitiba, Brazil., Franck CL; Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil., Dos Santos AFR; Pontifical Catholic University of Parana, Curitiba, Brazil., de Noronha L; Pontifical Catholic University of Parana, Curitiba, Brazil., Motamen S; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Valadan R; Molecular and Cell Biology Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Amjadi O; Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Gogna R; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation centre for Stem Cell Biology, DanStem, Faculty of Health and Medical Sciences, Champalimaud Centre for the Unknown, Lisbon, Portugal., Madan E; Campania Centre for the Unknown, Lisbon, Portugal., Alizadeh-Navaei R; Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran., Lamperti L; Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile., Zuñiga F; Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile., Nova-Lamperti E; Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile., Labarca G; Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.; Faculty of Medicine, Universidad de Concepcion, Concepcion, Chile., Knippenberg B; Infectious Diseases Department, Royal Darwin Hospital, Darwin, NT, Australia., Herwanto V; Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia., Wang Y; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.; Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia.; Department of Medicine, Sydney Medical School Nepean, Nepean Hospital, University of Sydney, Penrith, NSW, Australia., Phu A; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.; Westmead Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia., Chew T; Sydney Informatics Hub, Core Research Facilities, University of Sydney, Sydney, NSW, Australia., Kwan T; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia., Kim K; Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia., Teoh S; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia., Pelaia TM; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia., Kuan WS; Emergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Jee Y; Emergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore., Iredell J; Faculty of Medicine and Health, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.; Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Westmead Hospital, Western Sydney Local Health District, Sydney, NSW, Australia., O'Byrne K; Queensland University of Technology, Centre for Genomics and PersonalisedHealth, School of Biomedical Sciences, Brisbane, QLD, Australia., Fraser JF; Critical Care Research Group, The University of Queensland, Brisbane, QLD, Australia., Davis MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.; Department of Clinical Pathology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Belz GT; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Warkiani ME; Australia Centre for Health Technologies (CHT) & Institute for Biomedical Materials & Devices (IBMD), School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia., Gallo CS; Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.; Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, Australia., Souza-Fonseca-Guimaraes F; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Nguyen Q; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Mclean A; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia., Kulasinghe A; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Short KR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Tang B; Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.; Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Jan 05; Vol. 13, pp. 1060438. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.1060438
Abstrakt:	Purpose: Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients. Moreover, it is not clear whether such tools would apply to other potentially pandemic pathogens and therefore of use as stockpile for future pandemic preparedness. Methods: We conducted a multi-cohort observational study to investigate the biology and the prognostic role of interferon alpha-inducible protein 27 ( IFI27 ) in COVID-19 patients. Results: We show that IFI27 is expressed in the respiratory tract of COVID-19 patients and elevated IFI27 expression in the lower respiratory tract is associated with the presence of a high viral load. We further demonstrate that the systemic host response, as measured by blood IFI27 expression, is associated with COVID-19 infection. For clinical outcome prediction (e.g., respiratory failure), IFI27 expression displays a high sensitivity (0.95) and specificity (0.83), outperforming other known predictors of COVID-19 outcomes. Furthermore, IFI27 is upregulated in the blood of infected patients in response to other respiratory viruses. For example, in the pandemic H1N1/09 influenza virus infection, IFI27- like genes were highly upregulated in the blood samples of severely infected patients. Conclusion: These data suggest that prognostic biomarkers targeting the family of IFI27 genes could potentially supplement conventional diagnostic tools in future virus pandemics, independent of whether such pandemics are caused by a coronavirus, an influenza virus or another as yet-to-be discovered respiratory virus. Competing Interests: FS-F-G is a consultant for Biotheus Inc. KS is a consultant for Sanofi, Roche and NovoNordisk. The opinions and data presented in this manuscript are of the authors and are independent of these relationships. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Shojaei, Shamshirian, Monkman, Grice, Tran, Tan, Teo, Rodrigues Rossi, McCulloch, Nalos, Raei, Razavi, Ghasemian, Gheibi, Roozbeh, Sly, Spann, Chew, Zhu, Xia, Wells, Senegaglia, Kuniyoshi, Franck, dos Santos, Noronha, Motamen, Valadan, Amjadi, Gogna, Madan, Alizadeh-Navaei, Lamperti, Zuñiga, Nova-Lamperti, Labarca, Knippenberg, Herwanto, Wang, Phu, Chew, Kwan, Kim, Teoh, Pelaia, Kuan, Jee, Iredell, O’Byrne, Fraser, Davis, Belz, Warkiani, Gallo, Souza-Fonseca-Guimaraes, Nguyen, Mclean, Kulasinghe, Short and Tang.)
Databáze:	MEDLINE
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