Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection.

Autor:	Montaño Mendoza VM; Grupo Reproducción, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia., Mendez Cortina YA; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia., Rodríguez-Perea AL; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia., Fernandez GJ; Grupo Biología y Control de Enfermedades Infecciosas BCEI, Universidad de Antioquia - UdeA, Medellín, Colombia., Rugeles MT; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia., Velilla Hernandez PA; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia., Cardona Maya WD; Grupo Reproducción, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Jan; Vol. 9 (1), pp. e13045. Date of Electronic Publication: 2023 Jan 18.
DOI:	10.1016/j.heliyon.2023.e13045
Abstrakt:	For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men. Competing Interests: The authors declare that there are no conflicts of interest. (© 2023 The Authors.)
Databáze:	MEDLINE
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