[Liver injury due to COVID-19 in critically ill adult patients. A retrospective study].

Autor:	Alva NV; Departamento de Terapia Intensiva, Hospital Ángeles Mocel, México., Méndez OR; Departamento de Medicina Interna, Hospital Star Médica Centro, México., Gasca JC; Departamento de Terapia Intensiva, Hospital Juárez de México, México., Salvador I; Departamento de Terapia Intensiva, Hospital Ángeles Mocel, México., Hernández N; Departamento de Inhaloterapia, Centro Médico ABC, México., Valdez M; Departamento de Terapia Intensiva, Hospital Bicentenario, Aguascalientes, México.
Jazyk:	Spanish; Castilian
Zdroj:	Revista de gastroenterologia de Mexico [Rev Gastroenterol Mex] 2023 Jan 17. Date of Electronic Publication: 2023 Jan 17.
DOI:	10.1016/j.rgmx.2022.08.003
Abstrakt:	Introduction and Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients. Materials and Methods: A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range: 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission. Results: Gamma glutamyl transferase (GGT) levels were elevated (p = 0.032), as were those of AST (p = 0.011) and ALT (p = 0.021). The patients were stratified into age groups: 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R 2 association of 0.689, explained by AST, GGT, and C-reactive protein levels. Conclusions: Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed. (© 2023 Published by Masson Doyma México S.A. on behalf of Asociación Mexicana de Gastroenterología.)
Databáze:	MEDLINE
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