Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography.

Autor:	Delgorio PL; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., Hiscox LV; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., McIlvain G; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., Kramer MK; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., Diano AM; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., Twohy KE; Department of Mechanical Engineering, University of Delaware, Newark, DE, United States., Merritt AA; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States., McGarry MDJ; Thayer School of Engineering, Dartmouth College, Hanover, NH, United States., Schwarb H; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States., Daugherty AM; Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, MI, United States., Ellison JM; Swank Memory Care and Geriatric Consultation, ChristianaCare, Wilmington, DE, United States; Department of Communication Sciences and Disorders, University of Delaware, Newark, DE, United States., Lanzi AM; Department of Communication Sciences and Disorders, University of Delaware, Newark, DE, United States., Cohen ML; Department of Communication Sciences and Disorders, University of Delaware, Newark, DE, United States., Martens CR; Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States., Johnson CL; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States; Department of Mechanical Engineering, University of Delaware, Newark, DE, United States. Electronic address: clj@udel.edu.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2023; Vol. 37, pp. 103327. Date of Electronic Publication: 2023 Jan 18.
DOI:	10.1016/j.nicl.2023.103327
Abstrakt:	Hippocampal subfields (HCsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer's disease. Studies in aMCI patients often assess HCsf tissue integrity using measures of volume, which has little specificity to microstructure and pathology. We use magnetic resonance elastography (MRE) to examine the viscoelastic mechanical properties of HCsf tissue, which is related to structural integrity, and sensitively detect differences in older adults with aMCI compared to an age-matched control group. Group comparisons revealed HCsf viscoelasticity is differentially affected in aMCI, with CA1-CA2 and DG-CA3 exhibiting lower stiffness and CA1-CA2 exhibiting higher damping ratio, both indicating poorer tissue integrity in aMCI. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond measures of volume alone. Additionally, lower DG-CA3 stiffness predicted aMCI status regardless of DG-CA3 volume. These findings showcase the benefit of using MRE in detecting subtle pathological tissue changes in individuals with aMCI via the HCsf particularly affected in the disease. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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