Cross-sectional study of the proportion of antibiotic use during childbirth in full-term deliveries in Finland.

Autor: Gardemeister S; Children's Hospital, University of Helsinki, Stenbäckinkatu 11, FI-00029 HUS, Helsinki, Finland., Skogberg K; Division of Infectious Diseases, Inflammation Centre, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland., Saisto T; Department of Obstetrics and Gynaecology, Helsinki University Hospital, HUS, and University of Helsinki, Helsinki, Finland., Salonen A; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., de Vos WM; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands., Korpela K; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kolho KL; Children's Hospital, University of Helsinki, Stenbäckinkatu 11, FI-00029 HUS, Helsinki, Finland. kaija-leena.kolho@helsinki.fi.; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. kaija-leena.kolho@helsinki.fi.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. kaija-leena.kolho@helsinki.fi.
Jazyk: angličtina
Zdroj: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2023 Jan 21; Vol. 23 (1), pp. 50. Date of Electronic Publication: 2023 Jan 21.
DOI: 10.1186/s12884-023-05368-0
Abstrakt: Purpose: In developed countries, data on the frequency of antibiotics given to mothers during childbirth are limited beyond the overall effect of all various prophylactic indications. Also, data on the impact of such antibiotics to the well-being of term babies are scarce. We aimed to characterize the frequency of antibiotic use during childbirth of term pregnancy. Secondly, we assessed whether the use of antibiotics was associated with any symptoms in infants.
Methods: This was a cross-sectional study of 1019 term deliveries of women participating in the prospective Health and Early Life Microbiota (HELMi) birth cohort study between March 2016 and March 2018 in the capital region of Finland. The data on antibiotic use were collected from the hospital records.
Results: In total, 37% of the mothers received antibiotics during childbirth and 100% in Caesarean Sects. (17% of the deliveries). Less than 5% of antibiotics were non-prophylactic. In vaginal deliveries, the most common indication (18%) was prophylaxis for Group B Streptococcus. The most frequently used antibiotics were cefuroxime (22%) and benzylpenicillin (15%), and 56% received only one dose. In infants exposed to antibiotics during delivery, defecation frequency was higher during the first months (p-value < 0.0001- 0.0145), and weight gain was higher at the age of three months (p-value 0.0371).
Conclusion: More than every third new-born in a developed country is exposed to antibiotics during birth. Our findings support the hypothesis that maternal antibiotics given during birth have an impact on the well-being of the infants. These findings should inform current policies for prophylactic antibiotics in childbirth.
(© 2023. The Author(s).)
Databáze: MEDLINE
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