Influence of luminal and basal subtype in prognosis of high-grade non muscle invasive urothelial carcinoma.

Autor: Pérez-Montiel D; Departamento de Patología, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Olivares-Mundo A; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Jiménez-Ríos MA; Departamento de Urología, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Morera CS; Departamento de Patología, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Scavuzzo A; Departamento de Urología, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Orozco-Mora A; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico., Prada D; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, 10032, USA. Electronic address: dpradao@incan.edu.mx., Cantú-de León D; Dirección de Investigación, Instituto Nacional de Cancerología, San Fernando 22, Colonia Sección XVI, Tlalpan, Ciudad de México 14050, Mexico. Electronic address: dcantude@gmail.com.
Jazyk: angličtina
Zdroj: Annals of diagnostic pathology [Ann Diagn Pathol] 2023 Apr; Vol. 63, pp. 152081. Date of Electronic Publication: 2023 Jan 17.
DOI: 10.1016/j.anndiagpath.2022.152081
Abstrakt: Background: Recent studies have shown that the classification of high-grade urothelial carcinoma non-muscle invasive (HGBCNMI) based on molecular subtypes might be a valuable strategy to identify patients with a worse clinical prognosis.
Objective: Determine the effect of the luminal and basal molecular subtype determined by immunistochemical on prognosis in patients with HGBC in Mexican population.
Methods: Phenotypes were evaluated by immunohistochemical staining of luminal (GATA3, FOXA1) and basal (CK5/6, CK14) markers in paraffin-embedded tissue samples from 45 patients with a diagnosis of HGBCNMI treated at Instituto Nacional de Cancerología-México (INCan) between 2009 and 2019. The association with prognosis was evaluated using Kaplan-Meier curves and multivariable-adjusted Cox models.
Results: HGBCNMI patients showed mean age of 58.77 years (SD: ±12.08 years). We identified expression of the luminal molecular subtype in 35 cases (77.78 %), and 10 cases (22.22 %) with "combined" expression of the molecular subtype (basal and luminal expression). The combined phenotype was statistically more frequent in metastatic cases (p-value = 0.028). In Kaplan-Meier curves, combined expression of luminal and basal molecular markers was associated with disease progression (p-value = 0.002, log-rank test). Cox regression models confirmed this association, which was not influenced by age (p-value = 0.007) or gender (p-value = 0.007). No association of phenotypes with overall survival (p-value = 0.860) or relapse (p-value = 0.5) was observed.
Conclusion: The combined expression of immunohistochemical markers of the luminal and basal subtype might be considered as predictor for disease progression in patients with HGBCNMI in Mexican population.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interest in any form.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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