| Autor: |
Sikkema RS; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands., Bruin E; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands., Ramakers C; Clinical Chemistry, Erasmus MC, 3015 Rotterdam, The Netherlands., Bentvelsen R; Microvida Laboratory for Microbiology, Amphia Hospital, 4818 Breda, The Netherlands.; Department of Medical Microbiology, Leiden University Medical Center, 2333 Leiden, The Netherlands., Li W; Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands., Bosch BJ; Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands., Westerhuis B; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands., Haagmans B; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands., Koopmans MPG; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands., Fraaij PLA; Viroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.; Pediatrics, Erasmus MC-Sophia Children's Hospital, 3015 Rotterdam, The Netherlands. |
| Abstrakt: |
SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens. |
