Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas.

Autor: Plante JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA., Plante KS; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA., Popov VL; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA.; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA., Shinde DP; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA., Widen SG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0679, USA., Buenemann M; Department of Geography and Environmental Studies, New Mexico State University, Las Cruces, NM 88003-8801, USA., Nogueira ML; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Department of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto 15090-000, SP, Brazil., Vasilakis N; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, USA.; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.; Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2023 Jan 10; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 10.
DOI: 10.3390/v15010195
Abstrakt: Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex , and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5'- and 3'-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.
Databáze: MEDLINE
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