| Autor: |
Razanajatovo NH; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Randriambolamanantsoa TH; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Rabarison JH; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Randrianasolo L; Epidemiology and Clinical Research Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Ankasitrahana MF; Direction de la Veille Sanitaire, de la Surveillance Epidémiologique et Ripostes, Ministry of Public Health, Antananarivo 101, Madagascar., Ratsimbazafy A; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Raherinandrasana AH; Direction de la Veille Sanitaire, de la Surveillance Epidémiologique et Ripostes, Ministry of Public Health, Antananarivo 101, Madagascar., Razafimanjato H; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Raharinosy V; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Andriamandimby SF; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Heraud JM; Virology Department, Institut Pasteur de Dakar, Dakar 12900, Senegal., Dussart P; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar., Lacoste V; National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo 101, Madagascar. |
| Abstrakt: |
Three epidemic waves of coronavirus disease-19 (COVID-19) occurred in Madagascar from March 2020 to May 2022, with a positivity rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of 21% to 33%. Our study aimed to identify the impact of COVID-19 on the epidemiology of seasonal respiratory viruses (RVs) in Madagascar. We used two different specimen sources (SpS). First, 2987 nasopharyngeal (NP) specimens were randomly selected from symptomatic patients between March 2020 and May 2022 who tested negative for SARS-CoV-2 and were tested for 14 RVs by multiplex real-time PCR. Second, 6297 NP specimens were collected between March 2020 and May 2022 from patients visiting our sentinel sites of the influenza sentinel network. The samples were tested for influenza, respiratory syncytial virus (RSV), and SARS-CoV-2. From SpS-1, 19% (569/2987) of samples tested positive for at least one RV. Rhinovirus (6.3%, 187/2987) was the most frequently detected virus during the first two waves, whereas influenza predominated during the third. From SpS-2, influenza, SARS-CoV-2, and RSV accounted for 5.4%, 24.5%, and 39.4% of the detected viruses, respectively. During the study period, we observed three different RV circulation profiles. Certain viruses circulated sporadically, with increased activity in between waves of SARS-CoV-2. Other viruses continued to circulate regardless of the COVID-19 situation. Certain viruses were severely disrupted by the spread of SARS-CoV-2. Our findings underline the importance and necessity of maintaining an integrated disease surveillance system for the surveillance and monitoring of RVs of public health interest. |
