Mortality and Associated Factors in Patients with COVID-19: Cross-Sectional Study.

Autor:	Carvalho VP; Post-graduation course in Health Sciences at the Medical School, Federal University of Goiás (UFG), Goiânia 74690-900, GO, Brazil.; Department of Anesthesiology, Training and Teaching Center in Anesthesiology, Uberlândia 38400-448, MG, Brazil., Pontes JPJ; Department of Anesthesiology, Training and Teaching Center in Anesthesiology, Uberlândia 38400-448, MG, Brazil., Neto DRB; Department of Anesthesiology, Training and Teaching Center in Anesthesiology, Uberlândia 38400-448, MG, Brazil., Borges CER; Department of Anesthesiology, Training and Teaching Center in Anesthesiology, Uberlândia 38400-448, MG, Brazil., Campos GRL; Department of Anesthesiology, Training and Teaching Center in Anesthesiology, Uberlândia 38400-448, MG, Brazil., Ribeiro HLS; Department of Geriatrics, Brotherhood of the Santa Casa de Misericórdia de São Paulo, São Paulo 01221-010, SP, Brazil., Amaral WND; Post-graduation course in Health Sciences at the Medical School, Federal University of Goiás (UFG), Goiânia 74690-900, GO, Brazil.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2022 Dec 28; Vol. 11 (1). Date of Electronic Publication: 2022 Dec 28.
DOI:	10.3390/vaccines11010071
Abstrakt:	The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly virulent and causes coronavirus disease 2019 (COVID-19), resulting in high morbidity and mortality mainly associated with pulmonary complications. Because this virus is highly transmissible, it was quickly spread globally, resulting in COVID-19 being declared as a pandemic. This study aimed to analyze the prevalence of mortality and the factors related to mortality due to COVID-19 in patients with severe acute respiratory syndrome (SARS) at a university hospital in the Central—West region of Brazil. This retrospective cross-sectional study was based on an analysis of the medical records of patients with SARS aged >18 years and admitted to an intensive care unit due to COVID-19 with the requirement of invasive mechanical ventilation. Hospital death was considered as an outcome variable in this study. Moreover, demographic and lifestyle-related variables as well as the therapeutic measures used during the hospital stay were recorded and correlated with the death outcome. After excluding 188 medical records, 397 were analyzed. Most of the participants were men (59.7%), and the mortality rate in patients with SARS due to COVID-19 was 46.1%. Multiple regression analysis indicated that the independent factors associated with mortality in patients with SARS due to COVID-19 were the age of >60 years (p < 0.001) and the use of azithromycin (p = 0.012). Protective factors for mortality were considered as not having the following diseases: hyperthyroidism, asthma, hepatic inheritance, and not being a smoker. The mortality rate in patients with SARS due to COVID-19 was associated with older age and the use of azithromycin. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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