Personalized Dietary Advice to Increase Protein Intake in Older Adults Does Not Affect the Gut Microbiota, Appetite or Central Processing of Food Stimuli in Community-Dwelling Older Adults: A Six-Month Randomized Controlled Trial.

Autor:	Fluitman KS; Department of Internal Medicine, Amsterdam University Medical Center Location VUmc, 1081 HV Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, 1081 BT Amsterdam, The Netherlands., Wijdeveld M; Department of Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands., Davids M; Department of Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands., van Ruiten CC; Department of Internal Medicine, Amsterdam University Medical Center Location VUmc, 1081 HV Amsterdam, The Netherlands., Reinders I; Amsterdam Public Health Research Institute, 1081 BT Amsterdam, The Netherlands.; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, 1081 HV Amsterdam, The Netherlands., Wijnhoven HAH; Amsterdam Public Health Research Institute, 1081 BT Amsterdam, The Netherlands.; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, 1081 HV Amsterdam, The Netherlands., Keijser BJF; Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek (TNO) Earth, Life and Social Sciences, Department of Microbiology and Systems Biology, 3704 HE Zeist, The Netherlands.; Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, 1012 WX Amsterdam, The Netherlands., Visser M; Amsterdam Public Health Research Institute, 1081 BT Amsterdam, The Netherlands.; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, 1081 HV Amsterdam, The Netherlands., Nieuwdorp M; Department of Internal Medicine, Amsterdam University Medical Center Location VUmc, 1081 HV Amsterdam, The Netherlands.; Department of Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands., IJzerman RG; Department of Internal Medicine, Amsterdam University Medical Center Location VUmc, 1081 HV Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2023 Jan 09; Vol. 15 (2). Date of Electronic Publication: 2023 Jan 09.
DOI:	10.3390/nu15020332
Abstrakt:	Expert groups argue to raise the recommended daily allowance for protein in older adults from 0.8 to 1.2 g/kg/day to prevent undernutrition. However, protein is thought to increase satiety, possibly through effects on gut microbiota and central appetite regulation. If true, raising daily protein intake may work counterproductively. In a randomized controlled trial, we evaluated the effects of dietary advice aimed at increasing protein intake to 1.2 g/kg adjusted body weight/day (g/kg aBW/day) on appetite and gut microbiota in 90 community-dwelling older adults with habitual protein intake <1.0 g/kg aBW/day (Nintervention = 47, Ncontrol = 43). Food intake was determined by 24-h dietary recalls and gut microbiota by 16S rRNA sequencing. Functional magnetic resonance imaging (fMRI) scans were performed in a subgroup of 48 participants to evaluate central nervous system responses to food-related stimuli. Both groups had mean baseline protein intake of 0.8 ± 0.2 g/kg aBW/day. At 6 months’ follow-up this increased to 1.2 ± 0.2 g/kg aBW/day for the intervention group and 0.9 ± 0.2 g/kg aBW/day for the control group. Microbiota composition was not affected, nor were appetite or brain activity in response to food-related stimuli. Increasing protein intake in older adults to 1.2 g/kg aBW/day does not negatively impact the gut microbiota or suppress appetite.
Databáze:	MEDLINE
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