Cinnamomum sp. and Pelargonium odoratissimum as the Main Contributors to the Antibacterial Activity of the Medicinal Drink Horchata: A Study Based on the Antibacterial and Chemical Analysis of 21 Plants.

Autor: Fernandez-Soto P; Facultad de Ciencias de la Salud, Carrera de Enfermería, Grupo de Bio-Quimioinformática, Universidad de Las Américas (UDLA), Quito 170125, Ecuador., Celi D; Facultad de Ingeniería y Ciencias Aplicadas, Carrera de Ingeniería Agroindustrial, Universidad de Las Américas (UDLA), Quito 170125, Ecuador., Tejera E; Facultad de Ingeniería y Ciencias Agropecuarias Aplicadas, Grupo de Bio-Quimioinformática, Universidad de Las Américas (UDLA), Quito 170125, Ecuador., Alvarez-Suarez JM; Colegio de Ciencias e Ingenierías, Departamento de Ingeniería en Alimentos, Universidad San Francisco de Quito (USFQ), Quito 170901, Ecuador., Machado A; Colegio de Ciencias Biológicas y Ambientales (COCIBA), Instituto de Microbiología, Laboratorio de Bacteriología, Universidad San Francisco de Quito (USFQ), Quito 170901, Ecuador.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 10; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 10.
DOI: 10.3390/molecules28020693
Abstrakt: Horchata, a herbal infusion drink from Ecuador containing a mixture of medicinal plants, has been reported to exhibit anti-inflammatory, analgesic, diuretic, and antioxidant activity. The antibacterial activity of each of the plants contained in the horchata mixture has not been fully evaluated. Thus, in this study, we analysed the antibacterial activity of 21 plants used in horchata, collected from the Ecuadorian Andes region, against bacterial strains of clinical importance. The methanolic extract of Cinnamomum sp. showed minimal inhibitory concentration (MIC) values of 250 µg/mL against Staphylococcus aureus ATCC25923 and Methicillin-resistant S. aureus (MRSA), while Pelargonium odoratissimum exhibited a MIC value of 500 µg/mL towards S. aureus ATCC25923. The high-performance liquid chromatography-diode array detector-tandem mass spectrometry (HPLC-DAD-MS/MS) analyses identified in Cinnamomum sp. epicatechin tannins, cinnamaldehyde, and prehelminthosporol molecules, whereas in P. odoratissimum , gallocatechin and epigallocatechin tannins, some flavonoids, and gallic acid and derivatives were identified. Finally, Cinnamomum sp. and P. odoratissimum showed partial inhibition of biofilm formation of S. aureus ATCC25923 and MRSA. Overall, our findings revealed which of the plants used in horchata are responsible for the antibacterial activity attributed to this herbal drink and exhibit the potential for Cinnamomum sp. and P. odoratissimum secondary metabolites to be explored as scaffolds in drug development.
Databáze: MEDLINE
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