| Autor: |
Alsareii SA; Department of Surgery, College of Medicine, Najran University, Najran 11001, Saudi Arabia., Ahmad J; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia., Umar A; Department of Chemistry, Faculty of Science and Arts, Promising Centre for Sensors and Electronic Devices, Najran University, Najran 11001, Saudi Arabia., Ahmad MZ; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia., Shaikh IA; Department of Pharmacology, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 05; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 05. |
| DOI: |
10.3390/molecules28020545 |
| Abstrakt: |
These days an extensive amount of the attention of researchers is focused towards exploring bioactive compounds of natural or herbal origin for therapeutic intervention in different ailments of significant importance. One such novel bioactive compound that has a variety of biological properties, including anti-inflammatory and antioxidant activities, is piperine. However, until today, piperine has not been explored for its potential to improve inflammation and enhance healing in acute and chronic wounds. Therefore, the present study aimed to investigate the wound healing potential of piperine hydrogel formulation after topical application. Hydrogels fit the need for a depot system at the wound bed, where they ensure a consistent supply of therapeutic agents enclosed in their cross-linked network matrices. In the present study, piperine-containing carbopol 934 hydrogels mixed with Aloe vera gels of different gel strengths were prepared and characterized for rheological behavior, spreadability, extrudability, and percent (%) content uniformity. Furthermore, the wound healing potential of the developed formulation system was explored utilizing the excision wound healing model. The results of an in vivo study and histopathological examination revealed early and intrinsic healing of wounds with the piperine-containing bioactive hydrogel system compared to the bioactive hydrogel system without piperine. Therefore, the study's findings establish that the piperine-containing bioactive hydrogel system is a promising therapeutic approach for wound healing application that should be diligently considered for clinical transferability. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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