Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model.

Autor: Saka SO; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Salisu YY; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Sahabi HM; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Sanusi KO; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Ibrahim KG; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria.; Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 13110, Jordan., Abubakar MB; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Isa SA; Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Liman MG; Department of Pure and Applied Chemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Shehu S; Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Malami I; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria., Chan KW; Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, UPM, Serdang 43400, Selangor, Malaysia., Azmi NH; Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia., Imam MU; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto P.M.B. 2254, Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto P.M.B. 2346, Nigeria.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 05; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 05.
DOI: 10.3390/molecules28020532
Abstrakt: Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, fifteen cultivars of paddy rice that are predominantly consumed in North West Nigeria were analysed for their nutritional composition, bioactive contents and effects on metabolic outcomes in a fruit fly model. Gene expression analyses were conducted on the whole fly, targeting dPEPCK, dIRS, and dACC. The protein, carbohydrate, and fibre contents and bioactives of all BR cultivars were significantly different (p < 0.05) from the WR cultivars. Moreover, it was demonstrated that the glucose and trehalose levels were significantly higher (p < 0.05), while glycogen was significantly lower (p < 0.05) in the WR groups compared to the BR groups. Similarly, the expression of dACC and dPEPCK was upregulated, while that of dIRS was downregulated in the WR groups compared to the BR groups. Sex differences (p < 0.05) were observed in the WR groups in relation to the nutrigenomic effects. Our findings confirm metabolic perturbations in fruit flies following consumption of WR via distortion of insulin signalling and activation of glycogenolysis and gluconeogenesis. BR prevented these metabolic changes possibly due to its richer nutritional composition.
Databáze: MEDLINE
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