The Greifswald Post COVID Rehabilitation Study and Research (PoCoRe)-Study Design, Characteristics and Evaluation Tools.

Autor: Steinmetz A; Physical and Rehabilitation Medicine, Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany., Bahlmann S; Physical and Rehabilitation Medicine, Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Bergelt C; Department of Medical Psychology, University Medicine Greifswald, 17475 Greifswald, Germany., Bröker BM; Institute of Immunology, University Medicine Greifswald, 17475 Greifswald, Germany., Ewert R; Department of Internal Medicine, Pulmonary Diseases, University Medicine Greifswald, 17475 Greifswald, Germany., Felix SB; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany., Flöel A; Department of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany., Fleischmann R; Department of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany., Hoffmann W; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Holtfreter S; Institute of Immunology, University Medicine Greifswald, 17475 Greifswald, Germany., Nauck M; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Riemann K; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Scheer C; Department of Anaesthesiology and Intensive Care, University Medicine Greifswald, 17475 Greifswald, Germany., Stahl D; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Vogelgesang A; Department of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, 17475 Greifswald, Germany., Wiesmann U; Department of Medical Psychology, University Medicine Greifswald, 17475 Greifswald, Germany., Klinger-König J; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany., Walk R; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany., Gross S; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany., Lehnert K; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany., Fielitz J; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany., Dörr M; DZHK (German Center for Cardiovascular Research), University Medicine Greifswald, 17475 Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jan 12; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 12.
DOI: 10.3390/jcm12020624
Abstrakt: (1) Background: COVID-19 is often associated with significant long-term symptoms and disability, i.e., the long/post-COVID syndrome (PCS). Even after presumably mild COVID-19 infections, an increasing number of patients seek medical help for these long-term sequelae, which can affect various organ systems. The pathogenesis of PCS is not yet understood. Therapy has so far been limited to symptomatic treatment. The Greifswald Post COVID Rehabilitation Study (PoCoRe) aims to follow and deeply phenotype outpatients with PCS in the long term, taking a holistic and comprehensive approach to the analysis of their symptoms, signs and biomarkers. (2) Methods: Post-COVID outpatients are screened for symptoms in different organ systems with a standardized medical history, clinical examination, various questionnaires as well as physical and cardiopulmonary function tests. In addition, biomaterials are collected for the analysis of immunomodulators, cytokines, chemokines, proteome patterns as well as specific (auto)antibodies. Patients are treated according to their individual needs, adhering to the current standard of care. PoCoRe's overall aim is to optimize diagnostics and therapy in PCS patients.
Databáze: MEDLINE
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